BD 1008 dihydrobromide

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Cat.No. 0511 - BD 1008 dihydrobromide | C15H22Cl2N2.2HBr | CAS No. 138356-09-9
Description: Potent, selective σ ligand
Chemical Name: N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine dihydrobromide
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Potent and selective σ-ligand (Ki against [3H]-(+)-3-PPP = 0.34 nM).

Technical Data

M. Wt 463.08
Formula C15H22Cl2N2.2HBr
Storage Store at -20°C
CAS Number 138356-09-9
PubChem ID 45073417
InChI Key YTBUMHOSKIAYCZ-UHFFFAOYSA-N
Smiles Br.Br.CN(CCN1CCCC1)CCC1=CC=C(Cl)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.15 50

Preparing Stock Solutions

The following data is based on the product molecular weight 463.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.8 mL 21.59 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

De Costa et al (1992) Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines - structural requirements and binding affinity at the σ receptor. J.Med.Chem. 35 38 PMID: 1310114

Monnet et al (1996) Differentiation of σ ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices. Br.J.Pharmacol. 119 65 PMID: 8872358

Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571


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Keywords: BD 1008 dihydrobromide, supplier, Potent, selective, σ, sigma, ligand, General, Receptors, BD1008, dihydrobromide, Sigma-Related, Sigma-Related, Tocris Bioscience

2 Citations for BD 1008 dihydrobromide

Citations are publications that use Tocris products. Selected citations for BD 1008 dihydrobromide include:

Hiranita et al (2013) Stimulants as specific inducers of dopamine-independentσ agonist self-administration in rats. Neurochem Int 347 42633 PMID: 23908387

Hiranita et al (2011) Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. J Pharmacol Exp Ther 339 662 PMID: 21859929


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