BC 11-38

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Cat.No. 4496 - BC 11-38 | C15H16N2OS2 | CAS No. 686770-80-9
Description: Selective PDE11 inhibitor
Chemical Name: 6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for BC 11-38

BC 11-38 is a selective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.

Technical Data for BC 11-38

M. Wt 304.43
Formula C15H16N2OS2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 686770-80-9
PubChem ID 2052828
Smiles CCCSC1=NC(CCS3)=C3C(N1C2=CC=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BC 11-38

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.44 100
ethanol 6.09 20

Preparing Stock Solutions for BC 11-38

The following data is based on the product molecular weight 304.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.42 mL 32.85 mL
5 mM 0.66 mL 3.28 mL 6.57 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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References for BC 11-38

References are publications that support the biological activity of the product.

Ceyhan et al (2012) Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem.Biol. 19 155 PMID: 22284362

If you know of a relevant reference for BC 11-38, please let us know.

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Keywords: BC 11-38, BC 11-38 supplier, BC11-38, phosphodiesterase, pde, 11, inhibitors, inhibits, selective, Phosphodiesterases, 4496, Tocris Bioscience

1 Citation for BC 11-38

Citations are publications that use Tocris products. Selected citations for BC 11-38 include:

Lu and Sewer (2015) p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation. J Biol Chem 35 1223 PMID: 25605330

Do you know of a great paper that uses BC 11-38 from Tocris? Please let us know.

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