BC 11-38

Pricing Availability Delivery Time Qty
Cat.No. 4496 - BC 11-38 | C15H16N2OS2 | CAS No. 686770-80-9
Description: Selective PDE11 inhibitor
Chemical Name: 6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.

Technical Data

M. Wt 304.43
Formula C15H16N2OS2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 686770-80-9
PubChem ID 2052828
InChI Key YHNDCCKFNWDQGW-UHFFFAOYSA-N
Smiles CCCSC1=NC(CCS3)=C3C(N1C2=CC=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.44 100
ethanol 6.09 20

Preparing Stock Solutions

The following data is based on the product molecular weight 304.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.42 mL 32.85 mL
5 mM 0.66 mL 3.28 mL 6.57 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ceyhan et al (2012) Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem.Biol. 19 155 PMID: 22284362


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Keywords: BC11-38 phosphodiesterase pde 11 inhibitors inhibits selective Phosphodiesterases

1 Citation for BC 11-38

Citations are publications that use Tocris products. Selected citations for BC 11-38 include:

Lu and Sewer (2015) p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation. J Biol Chem 35 1223 PMID: 25605330


Do you know of a great paper that uses BC 11-38 from Tocris? If so please let us know.

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Literature in this Area

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Pathways for BC 11-38

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