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Biological Activity for Bazedoxifene acetate
Bazedoxifene acetate is a potent selective estrogen receptor modulator (SERM) (IC50 values are 26 and 99 nM for ERα and ERβ respectively). Inhibits 17β-estradiol-induced proliferation in MCF-7 cells. Co-treatment with Raloxifene (Cat No. 2280) completely abolishes raloxifene-induced stimulation of luminal epithelial cells and myometrium.
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for Bazedoxifene acetate
Technical Data for Bazedoxifene acetate
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Bazedoxifene acetate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Bazedoxifene acetate
The following data is based on the product molecular weight 530.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.88 mL||9.42 mL||18.84 mL|
|5 mM||0.38 mL||1.88 mL||3.77 mL|
|10 mM||0.19 mL||0.94 mL||1.88 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
Product Datasheets for Bazedoxifene acetate
References for Bazedoxifene acetate
References are publications that support the biological activity of the product.
Komm et al (2005) Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology 146 3999 PMID: 15961563
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Citations for Bazedoxifene acetate
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Literature in this Area
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