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Bazedoxifene acetate

Cat. No. 5263 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective estrogen receptor modulator (SERM)
Chemical Name: 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Bazedoxifene acetate

Bazedoxifene acetate is a potent selective estrogen receptor modulator (SERM) (IC50 values are 26 and 99 nM for ERα and ERβ respectively). Inhibits 17β-estradiol-induced proliferation in MCF-7 cells. Co-treatment with Raloxifene (Cat. No. 2280) completely abolishes raloxifene-induced stimulation of luminal epithelial cells and myometrium.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Bazedoxifene acetate

Bazedoxifene acetate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Bazedoxifene acetate

M. Wt 530.65
Formula C30H34N2O3.C2H4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 198481-33-3
PubChem ID 154256
InChI Key OMZAMQFQZMUNTP-UHFFFAOYSA-N
Smiles CC2=C(C3=CC=C(O)C=C3)N(CC4=CC=C(OCCN5CCCCCC5)C=C4)C1=CC=C(O)C=C12.OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bazedoxifene acetate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.06 100
ethanol 10.61 20

Preparing Stock Solutions for Bazedoxifene acetate

The following data is based on the product molecular weight 530.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.42 mL 18.84 mL
5 mM 0.38 mL 1.88 mL 3.77 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for Bazedoxifene acetate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Bazedoxifene acetate

References are publications that support the biological activity of the product.

Komm et al (2005) Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology 146 3999 PMID: 15961563

If you know of a relevant reference for Bazedoxifene acetate, please let us know.

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Citations for Bazedoxifene acetate

Citations are publications that use Tocris products.

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Literature in this Area

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Pathways for Bazedoxifene acetate

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.