Bazedoxifene acetate

Pricing Availability Delivery Time Qty
Cat.No. 5263 - Bazedoxifene acetate | C30H34N2O3.C2H4O2 | CAS No. 198481-33-3
Description: Potent and selective estrogen receptor modulator (SERM)
Chemical Name: 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Potent selective estrogen receptor modulator (SERM) (IC50 values are 26 and 99 nM for ERα and ERβ respectively). Inhibits 17β-estradiol-induced proliferation in MCF-7 cells. Co-treatment with Raloxifene (Cat No. 2280) completely abolishes raloxifene-induced stimulation of luminal epithelial cells and myometrium.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Bazedoxifene acetate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 530.65
Formula C30H34N2O3.C2H4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 198481-33-3
PubChem ID 154256
InChI Key OMZAMQFQZMUNTP-UHFFFAOYSA-N
Smiles CC2=C(C3=CC=C(O)C=C3)N(CC4=CC=C(OCCN5CCCCCC5)C=C4)C1=CC=C(O)C=C12.OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.06 100
ethanol 10.61 20

Preparing Stock Solutions

The following data is based on the product molecular weight 530.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.42 mL 18.84 mL
5 mM 0.38 mL 1.88 mL 3.77 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Komm et al (2005) Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology 146 3999 PMID: 15961563


If you know of a relevant reference for Bazedoxifene acetate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Estrogen and Related Receptor Modulators

Keywords: Bazedoxifene acetate, supplier, selective, estrogen, receptors, modulator, SERM, selective, for, ERα, Estrogen, and, Related, Receptors, Estrogen, and, Related, Receptors, Tocris Bioscience

Citations for Bazedoxifene acetate

Citations are publications that use Tocris products.

Currently there are no citations for Bazedoxifene acetate. Do you know of a great paper that uses Bazedoxifene acetate from Tocris? If so please let us know.

Reviews for Bazedoxifene acetate

There are currently no reviews for this product. Be the first to review Bazedoxifene acetate and earn rewards!

Have you used Bazedoxifene acetate?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for Bazedoxifene acetate

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.