Bazedoxifene acetate

Discontinued Product

Bazedoxifene acetate (Cat. No. 5263) has been withdrawn from sale for commercial reasons.
Description: Potent and selective estrogen receptor modulator (SERM)
Chemical Name: 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)

Biological Activity for Bazedoxifene acetate

Bazedoxifene acetate is a potent selective estrogen receptor modulator (SERM) (IC50 values are 26 and 99 nM for ERα and ERβ respectively). Inhibits 17β-estradiol-induced proliferation in MCF-7 cells. Co-treatment with Raloxifene (Cat. No. 2280) completely abolishes raloxifene-induced stimulation of luminal epithelial cells and myometrium.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Bazedoxifene acetate

Bazedoxifene acetate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Bazedoxifene acetate

M. Wt 530.65
Formula C30H34N2O3.C2H4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 198481-33-3
PubChem ID 154256
InChI Key OMZAMQFQZMUNTP-UHFFFAOYSA-N
Smiles CC2=C(C3=CC=C(O)C=C3)N(CC4=CC=C(OCCN5CCCCCC5)C=C4)C1=CC=C(O)C=C12.OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Bazedoxifene acetate

References for Bazedoxifene acetate

References are publications that support the biological activity of the product.

Komm et al (2005) Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology 146 3999 PMID: 15961563

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Citations for Bazedoxifene acetate

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Currently there are no citations for Bazedoxifene acetate.

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Pathways for Bazedoxifene acetate

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.