Discontinued ProductUnfortunately Batrachotoxin (Cat. No. 2914) has been withdrawn from sale for commercial reasons.
Potent neurotoxin that activates voltage-gated sodium channels. Shifts voltage-dependent activation to more negative potentials, inactivation is disabled and pore conductance and selectivity are altered (displays increased permeability for NH4+, K+ and Cs+ ions).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 538.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.86 mL||9.28 mL||18.56 mL|
|5 mM||0.37 mL||1.86 mL||3.71 mL|
|10 mM||0.19 mL||0.93 mL||1.86 mL|
|50 mM||0.04 mL||0.19 mL||0.37 mL|
References are publications that support the products' biological activity.
Li et al (2002) The batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate. Mol.Pharmacol. 61 905 PMID: 11901230
Bosmans et al (2004) The poison dart frog's batrachotoxin modulates NaV1.8. FEBS Lett. 577 245 PMID: 15527793
Wang et al (2006) How batrachotocin modifies the sodium channel permeation pathway: computer modeling and site-directed mutagenesis. Mol.Pharmacol. 69 788 PMID: 16354762
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Keywords: Batrachotoxin, supplier, voltage-gated, voltage-dependent, Na+, channel, activators, Sodium, NaV, Channels, neurotoxins, BTX, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience
Citations for Batrachotoxin
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