Home / Pharmacology / Ion Channels / Sodium Channels / Voltage-gated Sodium (NaV) Channels / Voltage-gated Sodium (NaV) Channel Activators / Batrachotoxin

Batrachotoxin

Cat. No. 2914 Submit a Review Datasheet / COA / SDS

Discontinued Product

Batrachotoxin (Cat. No. 2914) has been withdrawn from sale for commercial reasons.
Cat.No. 2914 - Batrachotoxin | C31H42N2O6 | CAS No. 23509-16-2
Description: Voltage-gated Na+ channel activator
Alternative Names: BTX
Chemical Name: (1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-Dodecahydro-9,12-dihydroxy-2-11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
Datasheet
Citations
Reviews
Literature (5)
Biological Activity Technical Data Datasheets References

Biological Activity

Potent neurotoxin that activates voltage-gated sodium channels. Shifts voltage-dependent activation to more negative potentials, inactivation is disabled and pore conductance and selectivity are altered (displays increased permeability for NH4+, K+ and Cs+ ions).

Technical Data

M. Wt 538.67
Formula C31H42N2O6
Storage Store at -20°C
CAS Number 23509-16-2
Smiles O[C@]1(O6)CC[C@@]2(C)[C@@](CC=C3[C@@]62[C@H](O)C[C@@]4(CN7C)[C@@](OCC7)3CC=C4[C@@H](OC(C5=C(C)NC=C5C)=O)C)([H])C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
Safety Datasheet

References

References are publications that support the biological activity of the product.

Li et al (2002) The batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate. Mol.Pharmacol. 61 905 PMID: 11901230

Bosmans et al (2004) The poison dart frog's batrachotoxin modulates NaV1.8. FEBS Lett. 577 245 PMID: 15527793

Wang et al (2006) How batrachotocin modifies the sodium channel permeation pathway: computer modeling and site-directed mutagenesis. Mol.Pharmacol. 69 788 PMID: 16354762

View Related Products by Target

View Related Products by Product Action

View all Voltage-gated Sodium (NaV) Channel Activators

Keywords: Batrachotoxin, Batrachotoxin supplier, voltage-gated, voltage-dependent, Na+, channel, activators, Sodium, NaV, Channels, neurotoxins, BTX, Voltage-gated, 2914, Tocris Bioscience

Citations for Batrachotoxin

Citations are publications that use Tocris products.

Currently there are no citations for Batrachotoxin.

Reviews for Batrachotoxin

There are currently no reviews for this product. Be the first to review Batrachotoxin and earn rewards!

Have you used Batrachotoxin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Epilepsy

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.