Batrachotoxin
Discontinued Product
Unfortunately Batrachotoxin (Cat. No. 2914) has been withdrawn from sale for commercial reasons.
Biological Activity
Potent neurotoxin that activates voltage-gated sodium channels. Shifts voltage-dependent activation to more negative potentials, inactivation is disabled and pore conductance and selectivity are altered (displays increased permeability for NH4+, K+ and Cs+ ions).
Technical Data
| M. Wt | 538.67 |
| Formula | C31H42N2O6 |
| Storage | Store at -20°C |
| CAS Number | 23509-16-2 |
| Smiles | O[C@]1(O6)CC[C@@]2(C)[C@@](CC=C3[C@@]62[C@H](O)C[C@@]4(CN7C)[C@@](OCC7)3CC=C4[C@@H](OC(C5=C(C)NC=C5C)=O)C)([H])C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 538.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.86 mL | 9.28 mL | 18.56 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.71 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.86 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
on-line. Please contact Customer Service.
References
References are publications that support the products' biological activity.
Li et al (2002) The batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate. Mol.Pharmacol. 61 905 PMID: 11901230
Bosmans et al (2004) The poison dart frog's batrachotoxin modulates NaV1.8. FEBS Lett. 577 245 PMID: 15527793
Wang et al (2006) How batrachotocin modifies the sodium channel permeation pathway: computer modeling and site-directed mutagenesis. Mol.Pharmacol. 69 788 PMID: 16354762
View Related Products by Target
View Related Products by Product Action
Keywords: Batrachotoxin, supplier, voltage-gated, voltage-dependent, Na+, channel, activators, Sodium, NaV, Channels, neurotoxins, BTX, Voltage-gated, Sodium, Channels, Tocris Bioscience
Citations for Batrachotoxin
Citations are publications that use Tocris products.
Currently there are no citations for Batrachotoxin.
Literature in this Area
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
Pain Research Product Guide
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
