Batrachotoxin

Discontinued Product

Unfortunately Batrachotoxin (Cat. No. 2914) has been withdrawn from sale for commercial reasons.
Cat.No. 2914 - Batrachotoxin | C31H42N2O6 | CAS No. 23509-16-2
Description: Voltage-gated Na+ channel activator
Alternative Names: BTX
Chemical Name: (1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-Dodecahydro-9,12-dihydroxy-2-11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
Datasheet
Citations
Literature

Biological Activity

Potent neurotoxin that activates voltage-gated sodium channels. Shifts voltage-dependent activation to more negative potentials, inactivation is disabled and pore conductance and selectivity are altered (displays increased permeability for NH4+, K+ and Cs+ ions).

Technical Data

M. Wt 538.67
Formula C31H42N2O6
Storage Store at -20°C
CAS Number 23509-16-2
Smiles O[C@]1(O6)CC[C@@]2(C)[C@@](CC=C3[C@@]62[C@H](O)C[C@@]4(CN7C)[C@@](OCC7)3CC=C4[C@@H](OC(C5=C(C)NC=C5C)=O)C)([H])C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 538.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.28 mL 18.56 mL
5 mM 0.37 mL 1.86 mL 3.71 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Li et al (2002) The batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate. Mol.Pharmacol. 61 905 PMID: 11901230

Bosmans et al (2004) The poison dart frog's batrachotoxin modulates NaV1.8. FEBS Lett. 577 245 PMID: 15527793

Wang et al (2006) How batrachotocin modifies the sodium channel permeation pathway: computer modeling and site-directed mutagenesis. Mol.Pharmacol. 69 788 PMID: 16354762

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Keywords: Batrachotoxin, supplier, voltage-gated, voltage-dependent, Na+, channel, activators, Sodium, NaV, Channels, neurotoxins, BTX, Voltage-gated, Sodium, Channels, Tocris Bioscience

Citations for Batrachotoxin

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