Banoxantrone dihydrochloride

Pricing Availability   Qty
Description: Prodrug topoisomerase II inhibitor
Alternative Names: AQ4N
Chemical Name: 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Banoxantrone dihydrochloride

Banoxantrone dihydrochloride is a bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.

Technical Data for Banoxantrone dihydrochloride

M. Wt 517.4
Formula C22H28N4O6.2HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 252979-56-9
PubChem ID 72941779
Smiles OC1=CC=C(O)C2=C1C(C(C(NCC[N+]([O-])(C)C)=CC=C3NCC[N+]([O-])(C)C)=C3C2=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Banoxantrone dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 25.87 50
DMSO 12.94 25

Preparing Stock Solutions for Banoxantrone dihydrochloride

The following data is based on the product molecular weight 517.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.87 mL 19.33 mL 38.65 mL
2.5 mM 0.77 mL 3.87 mL 7.73 mL
5 mM 0.39 mL 1.93 mL 3.87 mL
25 mM 0.08 mL 0.39 mL 0.77 mL

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Product Datasheets for Banoxantrone dihydrochloride

References for Banoxantrone dihydrochloride

References are publications that support the biological activity of the product.

Friery et al (2000) Enhancement of the anti-tumour effect of cyclophosph. by the bioreductive drugs AQ4N and tirapazamine. Br.J.Cancer 82 1469 PMID: 10780528

Patterson and McKeown (2000) AQ4N: a new approach to hypoxia-activated cancer chemotherapy. Br.J.Cancer 83 1589 PMID: 11104551

Mehibel et al (2009) Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N). Mol.Cancer Ther. 8 1261 PMID: 19435866

If you know of a relevant reference for Banoxantrone dihydrochloride, please let us know.

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Keywords: Banoxantrone dihydrochloride, Banoxantrone dihydrochloride supplier, AQ4N, prodrug, hypoxia, hypoxic, cytotoxic, topoisomerase, II, inhibitors, inhibits, antitumor, antitumour, chemotherapeutics, DNA, Topoisomerase, 4219, Tocris Bioscience

Citations for Banoxantrone dihydrochloride

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Literature in this Area

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Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells
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Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.