Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBanoxantrone dihydrochloride
Description: Prodrug topoisomerase II inhibitor
Alternative Names: AQ4N
Chemical Name: 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Banoxantrone dihydrochloride
Banoxantrone dihydrochloride is a bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.
Technical Data for Banoxantrone dihydrochloride
| M. Wt | 517.4 |
| Formula | C22H28N4O6.2HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 252979-56-9 |
| PubChem ID | 72941779 |
| InChI Key | SBWCPHUXRZRTDP-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(O)C2=C1C(C(C(NCC[N+]([O-])(C)C)=CC=C3NCC[N+]([O-])(C)C)=C3C2=O)=O.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Banoxantrone dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.87 | 50 | |
| DMSO | 12.94 | 25 |
Preparing Stock Solutions for Banoxantrone dihydrochloride
The following data is based on the product molecular weight 517.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.87 mL | 19.33 mL | 38.65 mL |
| 2.5 mM | 0.77 mL | 3.87 mL | 7.73 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.87 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.77 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Banoxantrone dihydrochloride
References for Banoxantrone dihydrochloride
References are publications that support the biological activity of the product.
Friery et al (2000) Enhancement of the anti-tumour effect of cyclophosph. by the bioreductive drugs AQ4N and tirapazamine. Br.J.Cancer 82 1469 PMID: 10780528
Patterson and McKeown (2000) AQ4N: a new approach to hypoxia-activated cancer chemotherapy. Br.J.Cancer 83 1589 PMID: 11104551
Mehibel et al (2009) Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N). Mol.Cancer Ther. 8 1261 PMID: 19435866
If you know of a relevant reference for Banoxantrone dihydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Banoxantrone dihydrochloride, Banoxantrone dihydrochloride supplier, AQ4N, prodrug, hypoxia, hypoxic, cytotoxic, topoisomerase, II, inhibitors, inhibits, antitumor, antitumour, chemotherapeutics, DNA, Topoisomerase, 4219, Tocris Bioscience
Citations for Banoxantrone dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Banoxantrone dihydrochloride. Do you know of a great paper that uses Banoxantrone dihydrochloride from Tocris? Please let us know.
Reviews for Banoxantrone dihydrochloride
There are currently no reviews for this product. Be the first to review Banoxantrone dihydrochloride and earn rewards!
Have you used Banoxantrone dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.