BADGE

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Cat.No. 1326 - BADGE | C21H24O4 | CAS No. 1675-54-3
Description: PPARγ antagonist
Alternative Names: Bisphenol A diglycidyl ether
Chemical Name: 2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

PPARγ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ. Acts as a PPARγ agonist in an ECV304 cell line. Also produces PPARγ-independent apoptosis of tumor cells via several mechanisms. Active in vivo.

Technical Data

M. Wt 340.42
Formula C21H24O4
Storage Desiccate at -20°C
Purity ≥95% (HPLC)
CAS Number 1675-54-3
PubChem ID 2286
InChI Key LCFVJGUPQDGYKZ-UHFFFAOYSA-N
Smiles CC(C)(C1=CC=C(OCC2CO2)C=C1)C1=CC=C(OCC2CO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.04 100
ethanol 17.02 50

Preparing Stock Solutions

The following data is based on the product molecular weight 340.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bishop-Bailey et al (2000) Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line. Br.J.Pharmacol. 131 651 PMID: 11030710

Cuzzocrea et al (2004) Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation. Eur.J.Pharmacol. 483 79 PMID: 14709329

Fehlberg et al (2003) Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO. Br.J.Pharmacol. 139 495 PMID: 12788809

Wright et al (2000) A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation. J.Biol.Chem. 275 1873 PMID: 10636887


If you know of a relevant reference for BADGE, please let us know.

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Keywords: PPARγ PPARgamma antagonists Peroxisome Proliferator-activating Receptors PPARs BisphenolA diglycidyl ether Bisphenol A diglycidyl ether PPARgamma Receptors

Citations for BADGE

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