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Biological Activity for B I09
B I09 is an IRE-1 RNase inhibitor (IC50 = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.
Compound Libraries for B I09
Technical Data for B I09
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for B I09
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for B I09
The following data is based on the product molecular weight 303.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.59 mL||32.97 mL||65.94 mL|
|2.5 mM||1.32 mL||6.59 mL||13.19 mL|
|5 mM||0.66 mL||3.3 mL||6.59 mL|
|25 mM||0.13 mL||0.66 mL||1.32 mL|
References for B I09
References are publications that support the biological activity of the product.
Tang et al (2014) Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J.Clin.Invest. 124 2585 PMID: 24812669
If you know of a relevant reference for B I09, please let us know.
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Keywords: B I09, B I09 supplier, BI09, IRE, inhibitors, inhibits, cell, permeable, in, vivo, active, RNAse, endonuclease, IRE1, 6009, Tocris Bioscience
Citations for B I09
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