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IRE-1 RNase inhibitor (IC50 = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 303.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.59 mL||32.97 mL||65.94 mL|
|2.5 mM||1.32 mL||6.59 mL||13.19 mL|
|5 mM||0.66 mL||3.3 mL||6.59 mL|
|25 mM||0.13 mL||0.66 mL||1.32 mL|
References are publications that support the biological activity of the product.
Tang et al (2014) Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J.Clin.Invest. 124 2585 PMID: 24812669
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Keywords: B I09, B I09 supplier, BI09, IRE, inhibitors, inhibits, cell, permeable, in, vivo, active, RNAse, endonuclease, IRE1, 6009, Tocris Bioscience
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