B I09

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Cat.No. 6009 - B I09 | C16H17NO5 | CAS No. 1607803-67-7
Description: IRE1 endonuclease inhibitor; cell permeable
Chemical Name: 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

IRE-1 RNase inhibitor (IC50 = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.

Technical Data

M. Wt 303.31
Formula C16H17NO5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1607803-67-7
PubChem ID 86290458
InChI Key UYYMWNUDIOPESF-UHFFFAOYSA-N
Smiles OC1=CC=C2C3=C(C(OC2=C1C4OCCCO4)=O)CNCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 303.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.48 mL 32.97 mL
5 mM 0.66 mL 3.3 mL 6.59 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Tang et al (2014) Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J.Clin.Invest. 124 2585 PMID: 24812669


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