You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for B I09
B I09 is an IRE-1 RNase inhibitor (IC50 = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.
Compound Libraries for B I09
Technical Data for B I09
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for B I09
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for B I09
The following data is based on the product molecular weight 303.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.59 mL||32.97 mL||65.94 mL|
|2.5 mM||1.32 mL||6.59 mL||13.19 mL|
|5 mM||0.66 mL||3.3 mL||6.59 mL|
|25 mM||0.13 mL||0.66 mL||1.32 mL|
References for B I09
References are publications that support the biological activity of the product.
Tang et al (2014) Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J.Clin.Invest. 124 2585 PMID: 24812669
If you know of a relevant reference for B I09, please let us know.
View Related Products by Product Action
Keywords: B I09, B I09 supplier, BI09, IRE, inhibitors, inhibits, cell, permeable, in, vivo, active, RNAse, endonuclease, IRE1, 6009, Tocris Bioscience
1 Citation for B I09
Citations are publications that use Tocris products. Selected citations for B I09 include:
Andrew V et al (2021) Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers. Cancer Res 81 5325-5335 PMID: 34548333
Do you know of a great paper that uses B I09 from Tocris? Please let us know.
Reviews for B I09
There are currently no reviews for this product. Be the first to review B I09 and earn rewards!
Have you used B I09?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets