Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Azurin p28 peptide is a 28 amino acid fragment of azurin (amino acids 50-77). The peptide is preferentially taken up by human breast cancer cell lines via caveolin-mediated endocytosis. Azurin p28 peptide binds wild-type and mutant p53 protein and inhibits E3 ligase COP1-mediated ubiquitination of p53 by >80%, resulting in decreased proteasomal degradation of p53. It induces cell cycle arrest in the G2/M phase leading to apoptosis. Azurin p28 peptide exhibits antiproliferative effects in human breast cancer cells in vitro and in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 2 mg/ml in 0.01M PBS|
References are publications that support the biological activity of the product.
Yaghoubi et al (2020) p28 bacterial peptide, as an anticancer agent. Front.Oncol. 10 1303 PMID: 32850408
Yamada et al (2013) p28, a first in class peptide inhibitor of cop1 binding to p53. Br.J.Cancer 108 2495 PMID: 23736031
Yamada et al (2009) A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol.Cancer Ther. 8 2947 PMID: 19808975
If you know of a relevant reference for Azurin p28 peptide, please let us know.
Keywords: Azurin p28 peptide, Azurin p28 peptide supplier, p53, binding, binds, COP1, E3, ligase, inhibitors, inhibits, breast, cancer, antiproliferative, tp53, Ubiquitin, Ligases, 7662, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for Azurin p28 peptide. Do you know of a great paper that uses Azurin p28 peptide from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review Azurin p28 peptide and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.