Azurin p28 peptide

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Description: Increases p53 levels; binds p53 and inhibits COP1-mediated ubiquitination of p53
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Pathways (1)

Biological Activity for Azurin p28 peptide

Azurin p28 peptide is a 28 amino acid fragment of azurin (amino acids 50-77). The peptide is preferentially taken up by human breast cancer cell lines via caveolin-mediated endocytosis. Azurin p28 peptide binds wild-type and mutant p53 protein and inhibits E3 ligase COP1-mediated ubiquitination of p53 by >80%, resulting in decreased proteasomal degradation of p53. It induces cell cycle arrest in the G2/M phase leading to apoptosis. Azurin p28 peptide exhibits antiproliferative effects in human breast cancer cells in vitro and in vivo.

Technical Data for Azurin p28 peptide

M. Wt 2914.2
Formula C122H197N31O47S2
Sequence LSTAADMQGVVTDGMASGLDKDYLKPDD
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 897026-25-4
PubChem ID 53363312
InChI Key RFGPECAMUVWTJN-AWHPYGDNSA-N
Smiles O=C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Azurin p28 peptide

Solubility Soluble to 2 mg/ml in 0.01M PBS

Product Datasheets for Azurin p28 peptide

References for Azurin p28 peptide

References are publications that support the biological activity of the product.

Yaghoubi et al (2020) p28 bacterial peptide, as an anticancer agent. Front.Oncol. 10 1303 PMID: 32850408

Yamada et al (2013) p28, a first in class peptide inhibitor of cop1 binding to p53. Br.J.Cancer 108 2495 PMID: 23736031

Yamada et al (2009) A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol.Cancer Ther. 8 2947 PMID: 19808975


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Keywords: Azurin p28 peptide, Azurin p28 peptide supplier, p53, binding, binds, COP1, E3, ligase, inhibitors, inhibits, breast, cancer, antiproliferative, tp53, Ubiquitin, Ligases, 7662, Tocris Bioscience

Citations for Azurin p28 peptide

Citations are publications that use Tocris products.

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Reviews for Azurin p28 peptide

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Literature in this Area

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for Azurin p28 peptide

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.