AZD 4547

Pricing Availability   Qty
Description: Potent and selective FGFR inhibitor
Chemical Name: rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity for AZD 4547

AZD 4547 is a potent and selective FGFR1, FGFR3 and FGFR2 tyrosine kinase inhibitor (IC50 values are 0.2 1.8, and 2.5 nM, respectively). It shows selectivity for FGFR across a range of unrelated tyrosine and serine/threonine kinases, including IGFR (>2,900-fold), CDK2 (>50,000-fold), and p38 (>50,000-fold). In vitro, it has antiproliferative effects on tumor cell lines with deregulated FGFR expression. In vivo, AZD 4547 exhibits dose-dependent inhibition of tumor growth in an FGFR-driven human tumor xenograft mice model. It suppresses osteoclastogenesis and tumor-induced osteolysis in an orthotopic breast cancer bone metastasis mouse model. AZD 4547 is orally bioavailable.

Technical Data for AZD 4547

M. Wt 463.56
Formula C26H33N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1035270-39-3
PubChem ID 51039095
InChI Key VRQMAABPASPXMW-HDICACEKSA-N
Smiles C[C@H]1CN(C2=CC=C(C=C2)C(NC3=NNC(CCC4=CC(OC)=CC(OC)=C4)=C3)=O)C[C@H](N1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 4547

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.27 20

Preparing Stock Solutions for AZD 4547

The following data is based on the product molecular weight 463.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.79 mL 53.93 mL 107.86 mL
1 mM 2.16 mL 10.79 mL 21.57 mL
2 mM 1.08 mL 5.39 mL 10.79 mL
10 mM 0.22 mL 1.08 mL 2.16 mL

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References for AZD 4547

References are publications that support the biological activity of the product.

Gavine et al (2012) AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res. 72 2045 PMID: 22369928

Kang et al (2019) A selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment. Sci.Rep. 9 8726 PMID: 31217507


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Keywords: AZD 4547, AZD 4547 supplier, AZD4547, potent, selective, tyrosine, kinases, inhibitors, inhibits, FGFR, orally, bioavailable, osteolysis, cancer, osteoclastogenesis, 7823, Tocris Bioscience

Citations for AZD 4547

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Literature in this Area

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