Home / Pharmacology / Enzymes / Transferases / Diacylglycerol O-Acyltransferase / Diacylglycerol O-Acyltransferase Inhibitors / AZD 3988

AZD 3988

Cat. No. 4837 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective DGAT-1 inhibitor
Chemical Name: trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AZD 3988

AZD 3988 is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for AZD 3988

AZD 3988 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AZD 3988

M. Wt 456.44
Formula C23H22F2N4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 892489-52-0
PubChem ID 23648867
InChI Key NGEBYTLALFOQKI-UHFFFAOYSA-N
Smiles O=C(NC3=CC=[C@@]([C@H]4CC[C@H](CC(O)=O)CC4)C=C3)C1=NN=C(NC2=CC(F)=C(F)C=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 3988

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.64 100
1eq. NaOH 4.56 10 with gentle warming

Preparing Stock Solutions for AZD 3988

The following data is based on the product molecular weight 456.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.95 mL 21.91 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.1 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for AZD 3988

References are publications that support the biological activity of the product.

McCoull et al (2012) Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg.Med.Chem.Lett. 22 3873 PMID: 22608962

If you know of a relevant reference for AZD 3988, please let us know.

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Keywords: AZD 3988, AZD 3988 supplier, AZD3988, potent, selective, diacylglycerol, transferases, DGAT1, inhibitors, inhibits, obesity, orally, bioavailable, cell, permeable, Diacylglycerol, O-Acyltransferase, 4837, Tocris Bioscience

3 Citations for AZD 3988

Citations are publications that use Tocris products. Selected citations for AZD 3988 include:

Mahoney et al (2019) A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition. Nat Commun 10 96 PMID: 30626880

Andris et al (2022) Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached. Cell Rep 39 110995 PMID: 35732120

Benedikt M et al (2019) A Novel Role for Triglyceride Metabolism in Foxp3 Expression. Front Immunol 10 1860 PMID: 31456800

Do you know of a great paper that uses AZD 3988 from Tocris? Please let us know.

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