Home / Pharmacology / Enzymes / Kinases / Pim Kinase / Pim Kinase Inhibitors / AZD 1208

AZD 1208

Cat. No. 6310 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent pan Pim kinase inhibitor
Chemical Name: (5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AZD 1208

AZD 1208 is a potent pan Pim kinase inhibitor (IC50 values are 0.4, 1.9 and 5.0 nM for Pim-1, 3 and 2, respectively). Exhibits >43-fold higher affinity for Pim kinases over a range of other kinases. Induces cell cycle arrest and apoptosis in AML cell lines in vitro and inhibits growth of tumor xenografts in vivo. AZD 1208 downmodulates the expression of Mayaro virus (MAYV) structural protein E1 and non-structural protein 1 (nsP1), and it reduces MAYV replication in a dose-dependent manner in HeLa or HDFs cells. Chemosensitizer.

Technical Data for AZD 1208

M. Wt 379.48
Formula C21H21N3O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1204144-28-4
PubChem ID 58423153
InChI Key MCUJKPPARUPFJM-UWCCDQBKSA-N
Smiles N[C@@H]1CCCN(C2=C(C3=CC=CC=C3)C=CC=C2/C=C4SC(NC\4=O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 1208

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.59 20 with gentle warming

Preparing Stock Solutions for AZD 1208

The following data is based on the product molecular weight 379.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.18 mL 65.88 mL 131.76 mL
1 mM 2.64 mL 13.18 mL 26.35 mL
2 mM 1.32 mL 6.59 mL 13.18 mL
10 mM 0.26 mL 1.32 mL 2.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for AZD 1208

References are publications that support the biological activity of the product.

Keeton et al (2014) AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood 123 905 PMID: 24363397

Brasó-Maristany et al (2016) PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nat.Med. 22 1303 PMID: 27775704

Dakin et al (2012) Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg.Med.Chem.Lett. 22 4599 PMID: 22727640

Salazar et al (2022) Targeting host PIM protein kinases reduces Mayaro virus replication. Viruses 14 422 PMID: 35216015

If you know of a relevant reference for AZD 1208, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Pim Kinase Inhibitors

Keywords: AZD 1208, AZD 1208 supplier, AZD1208, pan, Pim, kinase, 1, 2, 3, potent, active, in, vivo, anticancer, inhibitors, inhibits, chemosensitizer, antiviral, effects, against, Mayaro, virus, Kinase, Other, Antivirals, 6310, Tocris Bioscience

1 Citation for AZD 1208

Citations are publications that use Tocris products. Selected citations for AZD 1208 include:

Salazar et al (2022) Targeting host PIM protein kinases reduces Mayaro virus replication. Viruses 14 422 PMID: 35216015

Do you know of a great paper that uses AZD 1208 from Tocris? Please let us know.

Reviews for AZD 1208

There are currently no reviews for this product. Be the first to review AZD 1208 and earn rewards!

Have you used AZD 1208?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review