You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent pan Pim kinase inhibitor (IC50 values are 0.4, 1.9 and 5.0 nM for Pim-1, 3 and 2, respectively). Exhibits >43-fold higher affinity for Pim kinases over a range of other kinases. Induces cell cycle arrest and apoptosis in AML cell lines in vitro and inhibits growth of tumor xenografts in vivo. Chemosensitizer.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||7.59||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 379.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.18 mL||65.88 mL||131.76 mL|
|1 mM||2.64 mL||13.18 mL||26.35 mL|
|2 mM||1.32 mL||6.59 mL||13.18 mL|
|10 mM||0.26 mL||1.32 mL||2.64 mL|
References are publications that support the biological activity of the product.
Keeton et al (2014) AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood 123 905 PMID: 24363397
Brasó-Maristany et al (2016) PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nat.Med. 22 1303 PMID: 27775704
Dakin et al (2012) Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg.Med.Chem.Lett. 22 4599 PMID: 22727640
If you know of a relevant reference for AZD 1208, please let us know.
View Related Products by Product Action
Keywords: AZD 1208, AZD 1208 supplier, AZD1208, pan, Pim, kinase, 1, 2, 3, potent, active, in, vivo, anticancer, inhibitors, inhibits, chemosensitizer, Kinase, 6310, Tocris Bioscience
Citations for AZD 1208
Citations are publications that use Tocris products.
Currently there are no citations for AZD 1208. Do you know of a great paper that uses AZD 1208 from Tocris? Please let us know.
Reviews for AZD 1208
There are currently no reviews for this product. Be the first to review AZD 1208 and earn rewards!
Have you used AZD 1208?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.