AZ 13705339

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Cat.No. 6177 - AZ 13705339 | C33H36FN7O3S | CAS No. 2016806-57-6
Description: Highly potent PAK1 and PAK2 inhibitor
Chemical Name: 2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Highly potent PAK1 and PAK2 inhibitor (IC50 values are 0.33 and 6 nM for PAK1 and PAK2, respectively). Displays >7500-fold selectivity for PAK1 over PAK4 (IC50 = 2.6 μM).

Technical Data

M. Wt 629.75
Formula C33H36FN7O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2016806-57-6
PubChem ID 129909860
InChI Key WPFLVPJXKWCRQK-UHFFFAOYSA-N
Smiles CCS(=O)(C1=C(N2CCN(CC2)C)C=CC(NC3=NC=C(C(N(C4=CC(CO)=CC=C4C)CC5=C(C#N)C=CC=C5)=N3)F)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 62.98 100
ethanol 12.6 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 629.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.94 mL 15.88 mL
5 mM 0.32 mL 1.59 mL 3.18 mL
10 mM 0.16 mL 0.79 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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References

References are publications that support the biological activity of the product.

McCoull et al (2016) Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors. ACS Med.Chem.Lett. 7 1118 PMID: 27994749


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Citations for AZ 13705339

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