AZ 13705339

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Description: Highly potent PAK1 and PAK2 inhibitor
Chemical Name: 2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile
Purity: ≥98% (HPLC)

Biological Activity for AZ 13705339

AZ 13705339 is a highly potent PAK1 and PAK2 inhibitor (IC50 values are 0.33 and 6 nM for PAK1 and PAK2, respectively). Displays >7500-fold selectivity for PAK1 over PAK4 (IC50 = 2.6 μM).

Compound Libraries for AZ 13705339

AZ 13705339 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ 13705339

M. Wt 629.75
Formula C33H36FN7O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2016806-57-6
PubChem ID 129909860
Smiles CCS(=O)(C1=C(N2CCN(CC2)C)C=CC(NC3=NC=C(C(N(C4=CC(CO)=CC=C4C)CC5=C(C#N)C=CC=C5)=N3)F)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZ 13705339

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 62.98 100
ethanol 12.6 20 with gentle warming

Preparing Stock Solutions for AZ 13705339

The following data is based on the product molecular weight 629.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.94 mL 15.88 mL
5 mM 0.32 mL 1.59 mL 3.18 mL
10 mM 0.16 mL 0.79 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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References for AZ 13705339

References are publications that support the biological activity of the product.

McCoull et al (2016) Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors. ACS Med.Chem.Lett. 7 1118 PMID: 27994749

If you know of a relevant reference for AZ 13705339, please let us know.

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Citations for AZ 13705339

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