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Highly potent PAK1 and PAK2 inhibitor (IC50 values are 0.33 and 6 nM for PAK1 and PAK2, respectively). Displays >7500-fold selectivity for PAK1 over PAK4 (IC50 = 2.6 μM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||12.6||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 629.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.59 mL||7.94 mL||15.88 mL|
|5 mM||0.32 mL||1.59 mL||3.18 mL|
|10 mM||0.16 mL||0.79 mL||1.59 mL|
|50 mM||0.03 mL||0.16 mL||0.32 mL|
References are publications that support the biological activity of the product.
McCoull et al (2016) Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors. ACS Med.Chem.Lett. 7 1118 PMID: 27994749
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Keywords: AZ 13705339, AZ 13705339 supplier, AZ13705339, PAK1, PAK2, Group, I, inhibitors, inhibits, P21, activated, kinase, highly, potent, P21-activated, Kinases, 6177, Tocris Bioscience
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Reviews for AZ 13705339
Average Rating: 5 (Based on 1 Review.)
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10 nM of the compound inhibits the expression of PAK2 protein, assessed by western blotting.
Literature in this Area
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