Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAY 77
Description: Potent PAR2 biased agonist; exhibits bias for Ca2+ signaling
Purity: ≥95% (HPLC)
Biological Activity for AY 77
AY 77 is a potent PAR2 biased agonist. AY 77 exhibits bias for Ca2+ over ERK1/2 signaling (EC50 values are 40 nM for Ca2+ release versus 2 μM for ERK1/2 phosphorylation). Shows selectivity for PAR2 over PAR1. Promotes migration of human breast cancer cells in vitro.
Technical Data for AY 77
| M. Wt | 404.5 |
| Formula | C21H32N4O4 |
| Sequence |
XX (Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1835734-92-3 |
| PubChem ID | 137654325 |
| InChI Key | CAYJNBJPGBBDAS-WMZOPIPTSA-N |
| Smiles | O=C(N[C@H](C(N[C@H](C(N)=O)C1CCCCC1)=O)CC2CCCCC2)C3=CC=NO3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AY 77
| Solubility | Soluble to 1 mg/ml in ethanol |
Product Datasheets for AY 77
References for AY 77
References are publications that support the biological activity of the product.
Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521
Yau et al (2015) Potent small agonists of protease activated receptor 2. ACS Med.Chem.Lett. 7 105 PMID: 26819675
If you know of a relevant reference for AY 77, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: AY 77, AY 77 supplier, AY77, PAR2, biased, agonists, agonism, potent, proteinase, protease-activated, receptor, 2, Ca2+, calcium, signaling, GPR11, Protease-Activated, Receptors, 7033, Tocris Bioscience
Citations for AY 77
Citations are publications that use Tocris products.
Currently there are no citations for AY 77. Do you know of a great paper that uses AY 77 from Tocris? Please let us know.
Reviews for AY 77
There are currently no reviews for this product. Be the first to review AY 77 and earn rewards!
Have you used AY 77?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image