AY 77

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Cat.No. 7033 - AY 77 | 5-Isox-Cha-Chg-NH2 | CAS No. 1835734-92-3
Description: Potent PAR2 biased agonist; exhibits bias for Ca2+ signaling
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for AY 77

AY 77 is a potent PAR2 biased agonist. AY 77 exhibits bias for Ca2+ over ERK1/2 signaling (EC50 values are 40 nM for Ca2+ release versus 2 μM for ERK1/2 phosphorylation). Shows selectivity for PAR2 over PAR1. Promotes migration of human breast cancer cells in vitro.

Technical Data for AY 77

M. Wt 404.5
Formula C21H32N4O4
Sequence XX

(Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1835734-92-3
PubChem ID 137654325
InChI Key CAYJNBJPGBBDAS-WMZOPIPTSA-N
Smiles O=C(N[C@H](C(N[C@H](C(N)=O)C1CCCCC1)=O)CC2CCCCC2)C3=CC=NO3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AY 77

Solubility Soluble to 1 mg/ml in ethanol

References for AY 77

References are publications that support the biological activity of the product.

Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521

Yau et al (2015) Potent small agonists of protease activated receptor 2. ACS Med.Chem.Lett. 7 105 PMID: 26819675


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Citations for AY 77

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