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Submit ReviewAY 77
Description: Potent PAR2 biased agonist; exhibits bias for Ca2+ signaling
Purity: ≥95% (HPLC)
Biological Activity for AY 77
AY 77 is a potent PAR2 biased agonist. AY 77 exhibits bias for Ca2+ over ERK1/2 signaling (EC50 values are 40 nM for Ca2+ release versus 2 μM for ERK1/2 phosphorylation). Shows selectivity for PAR2 over PAR1. Promotes migration of human breast cancer cells in vitro.
Technical Data for AY 77
| M. Wt | 404.5 |
| Formula | C21H32N4O4 |
| Sequence |
XX (Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1835734-92-3 |
| PubChem ID | 137654325 |
| InChI Key | CAYJNBJPGBBDAS-WMZOPIPTSA-N |
| Smiles | O=C(N[C@H](C(N[C@H](C(N)=O)C1CCCCC1)=O)CC2CCCCC2)C3=CC=NO3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AY 77
References for AY 77
References are publications that support the biological activity of the product.
Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521
Yau et al (2015) Potent small agonists of protease activated receptor 2. ACS Med.Chem.Lett. 7 105 PMID: 26819675
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Keywords: AY 77, AY 77 supplier, AY77, PAR2, biased, agonists, agonism, potent, proteinase, protease-activated, receptor, 2, Ca2+, calcium, signaling, GPR11, Protease-Activated, Receptors, 7033, Tocris Bioscience
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