Avasimibe

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Cat.No. 6505 - Avasimibe | C29H43NO4S | CAS No. 166518-60-1
Description: ACAT inhibitor
Chemical Name: 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

ACAT inhibitor (IC50 = 3.3 μM). Inhibits cholesterol esterification and reduces plasma cholesterol levels in rats. Also inhibits tumor growth and prolongs survival time in a melanoma mouse model and reduces tumor growth and metastasis in a pancreatic cancer mouse model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 501.72
Formula C29H43NO4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 166518-60-1
PubChem ID 166558
InChI Key PTQXTEKSNBVPQJ-UHFFFAOYSA-N
Smiles CC(C1=CC(C(C)C)=C(C(C(C)C)=C1)CC(NS(=O)(OC2=C(C(C)C)C=CC=C2C(C)C)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.17 100
ethanol 10.03 20

Preparing Stock Solutions

The following data is based on the product molecular weight 501.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.93 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Lee et al (1996) Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets. J.Med.Chem. 39 5031 PMID: 8978833

Yang et al (2016) Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature 531 651 PMID: 26982734

Li et al (2016) Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer. Oncogene 35 6378 PMID: 27132508


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Keywords: Avasimibe, Avasimibe supplier, CI-1011, ACAT, inhibits, inhibitors, acyl-CoA:cholesterol, O-acyl, transferase, antitumor, Acyl-CoAcholesterol, acyltransferase, Acyl-CoA:Cholesterol, Acyltransferase, 6505, Tocris Bioscience

Citations for Avasimibe

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