ATPA

Pricing Availability Delivery Time Qty
Cat.No. 1107 - ATPA | C10H16N2O4 | CAS No. 140158-50-5
Description: Selective, potent GluR5 agonist
Chemical Name: (RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

A selective and potent GluR5 kainate receptor agonist (Ki = 4.3 nM), inactive at GluR6 (Ki > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (Ki values of 6 - 14 μM). Also available as part of the Kainate Receptor Tocriset™.

Technical Data

M. Wt 228.25
Formula C10H16N2O4
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 140158-50-5
PubChem ID 2253
InChI Key PIXJURSCCVBKRF-UHFFFAOYSA-N
Smiles CC(C)(C)C1=C(CC(N)C(O)=O)C(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 22.82 100
water 2.28 10

Preparing Stock Solutions

The following data is based on the product molecular weight 228.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.38 mL 21.91 mL 43.81 mL
5 mM 0.88 mL 4.38 mL 8.76 mL
10 mM 0.44 mL 2.19 mL 4.38 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Clarke et al (1997) A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389 599 PMID: 9335499

Matzen et al (1997) AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid. J.Med.Chem. 40 520 PMID: 9046343

Moldrich et al (1999) Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures. Eur.J.Pharmacol. 378 R1 PMID: 10478637


If you know of a relevant reference for ATPA, please let us know.

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Keywords: Selective potent GluR5 agonists Glutamate Kainate Receptors iGlur Ionotropic Kainate Receptors

5 Citations for ATPA

Citations are publications that use Tocris products. Selected citations for ATPA include:

Randall et al (2011) Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro. Eur J Neurosci 33 914 PMID: 21255131

Dargan et al (2009) ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology 56 121 PMID: 18789344

Xu et al (2006) Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Mol Pain 2 29 PMID: 16948848

Liu et al (2004) Astrocyte-mediated activation of neuronal kainate receptors. Mol Pain 101 3172 PMID: 14766987

Song et al (2015) Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice. Front Pediatr 11 25 PMID: 25933605


Do you know of a great paper that uses ATPA from Tocris? If so please let us know.

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Pathways for ATPA

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