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Description: Potent and selective GluK1 kainate agonist
Chemical Name: (RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
Purity: ≥98% (HPLC)
Citations (7)
Literature (3)

Biological Activity for ATPA

ATPA is a selective and potent GluK1 (formerly GluR5) kainate receptor agonist (Ki = 4.3 nM), inactive at GluK6 (formerly GluR6) (Ki > 1 mM) and only weakly active at AMPA receptors (GluA1-4) and the kainate receptors GluK5 (formerly KA-2) and GluK3 (formerly GluR7) (Ki values of 6 - 14 μM).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for ATPA

M. Wt 228.25
Formula C10H16N2O4
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 140158-50-5
PubChem ID 2253
Smiles CC(C)(C)C1=C(CC(N)C(O)=O)C(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ATPA

Solvent Max Conc. mg/mL Max Conc. mM
water 2.28 10 with gentle warming
1eq. NaOH 4.57 20 with gentle warming

Preparing Stock Solutions for ATPA

The following data is based on the product molecular weight 228.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 21.91 mL 109.53 mL 219.06 mL
1 mM 4.38 mL 21.91 mL 43.81 mL
2 mM 2.19 mL 10.95 mL 21.91 mL
10 mM 0.44 mL 2.19 mL 4.38 mL

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Product Datasheets for ATPA

Certificate of Analysis / Product Datasheet
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References for ATPA

References are publications that support the biological activity of the product.

Clarke et al (1997) A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389 599 PMID: 9335499

Matzen et al (1997) AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid. J.Med.Chem. 40 520 PMID: 9046343

Moldrich et al (1999) Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures. Eur.J.Pharmacol. 378 R1 PMID: 10478637

If you know of a relevant reference for ATPA, please let us know.

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Keywords: ATPA, ATPA supplier, Selective, potent, GluR5, agonists, Glutamate, Kainate, Receptors, iGlur, Ionotropic, GluK1, 1107, Tocris Bioscience

7 Citations for ATPA

Citations are publications that use Tocris products. Selected citations for ATPA include:

Randall et al (2011) Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro. Eur J Neurosci 33 914 PMID: 21255131

Dargan et al (2009) ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology 56 121 PMID: 18789344

Langner et al (2017) Kynurenic Acid Induces Impairment of Oligodendrocyte Viability: On the Role of Glutamatergic Mechanisms. Neurochem Res 42 838 PMID: 27444613

Talpalar and Kiehn (2010) Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG. Front Neural Circuits 4 PMID: 20844601

Do you know of a great paper that uses ATPA from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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