Atorvastatin hemicalcium salt

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Cat.No. 3776 - Atorvastatin hemicalcium salt | C33H34FN2O5.½Ca | CAS No. 134523-03-8
Description: Potent HMG-CoA reductase inhibitor
Alternative Names: Lipitor
Chemical Name: (R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Atorvastatin hemicalcium salt is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 577.67
Formula C33H34FN2O5.½Ca
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 134523-03-8
PubChem ID 60822
InChI Key FQCKMBLVYCEXJB-MNSAWQCASA-L
Smiles [Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 57.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 577.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.73 mL 8.66 mL 17.31 mL
5 mM 0.35 mL 1.73 mL 3.46 mL
10 mM 0.17 mL 0.87 mL 1.73 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Istvan et al (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292 1160 PMID: 11349148

Vaughan et al (2004) Update on statins: 2003. Circulation 110 886 PMID: 15313959

Santodomingo-Garzon et al (2006) Atorvastatin inhibits inflammatory hypernociception. Br.J.Pharmacol. 149 14 PMID: 16865092

Turner et al (2007) Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458 PMID: 18049315


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Keywords: Atorvastatin hemicalcium salt, supplier, HMG-CoA, reductases, inhibitors, inhibits, cholesterol, biosynthesis, LDL, Pfizer, Lipitor, HMG-CoA, Reductase, HMG-CoA, Reductase, Tocris Bioscience

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