ATC 0065

Discontinued Product

ATC 0065 (Cat. No. 3359) has been withdrawn from sale for commercial reasons.
Description: Potent and selective MCH1 antagonist
Chemical Name: N2-[cis-4-[[2-[4-Bromo-2-(trifluoromethoxy)phenyl]ethyl]amino]cyclohexyl]-N4,N4-dimethyl-2,4-quinazolinediamine dihydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for ATC 0065

Orally active, potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 15.7 nM) that displays > 96-fold selectivity over MCH2. Exhibits antidepressant and anxiolytic activity in vivo. Also displays affinity for 5-HT1A and 5-HT2B receptors (IC50 values are 62.9 and 266 nM respectively).

Technical Data for ATC 0065

M. Wt 625.35
Formula C25H29BrF3N5O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 510732-84-0
PubChem ID 11479128
Smiles BrC(C=C4)=CC(OC(F)(F)F)=C4CCN[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ATC 0065

References are publications that support the biological activity of the product.

Kanuma et al (2006) Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists. Bioorg.Med.Chem. 14 3307 PMID: 16434202

Chaki et al (2005) Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: Nonpeptide and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 313 832

Dyck et al (2005) Small molecule melanin-concentrating hormone receptor 1 (MCH1R) antagonists as anxiolytic and antidepressive agents. Drug Dev.Res. 65 291

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Keywords: ATC 0065, ATC 0065 supplier, potent, selective, MCH, MCHR, MCH1R, MCHR1, antagonists, melanin, concentrating, hormone, receptors, serotonin, 5HT, ATC0065, Melanin-concentrating, Hormone, Receptors, 3359, Tocris Bioscience

Citations for ATC 0065

Citations are publications that use Tocris products.

Currently there are no citations for ATC 0065.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.