ATC 0065

Discontinued Product

ATC 0065 (Cat. No. 3359) has been withdrawn from sale for commercial reasons.
Cat.No. 3359 - ATC 0065 | C25H29BrF3N5O.2HCl | CAS No. 510732-84-0
Description: Potent and selective MCH1 antagonist
Chemical Name: N2-[cis-4-[[2-[4-Bromo-2-(trifluoromethoxy)phenyl]ethyl]amino]cyclohexyl]-N4,N4-dimethyl-2,4-quinazolinediamine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Orally active, potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 15.7 nM) that displays > 96-fold selectivity over MCH2. Exhibits antidepressant and anxiolytic activity in vivo. Also displays affinity for 5-HT1A and 5-HT2B receptors (IC50 values are 62.9 and 266 nM respectively).

Technical Data

M. Wt 625.35
Formula C25H29BrF3N5O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 510732-84-0
PubChem ID 11479128
InChI Key BPGUWYBAINNZQH-UHFFFAOYSA-N
Smiles BrC(C=C4)=CC(OC(F)(F)F)=C4CCN[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Kanuma et al (2006) Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists. Bioorg.Med.Chem. 14 3307 PMID: 16434202

Chaki et al (2005) Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: Nonpeptide and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 313 832

Dyck et al (2005) Small molecule melanin-concentrating hormone receptor 1 (MCH1R) antagonists as anxiolytic and antidepressive agents. Drug Dev.Res. 65 291

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Keywords: ATC 0065, ATC 0065 supplier, potent, selective, MCH, MCHR, MCH1R, MCHR1, antagonists, melanin, concentrating, hormone, receptors, serotonin, 5HT, ATC0065, Melanin-concentrating, Hormone, Receptors, 3359, Tocris Bioscience

Citations for ATC 0065

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