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AT 56

Cat. No. 3531 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: L-PGDS inhibitor
Chemical Name: 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AT 56

AT 56 is an orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki = 75 μM, IC50 = 95 μM). Inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.

Compound Libraries for AT 56

AT 56 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AT 56

M. Wt 397.52
Formula C25H27N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 162640-98-4
PubChem ID 11741525
InChI Key LQNGMDUIRLSESZ-UHFFFAOYSA-N
Smiles C2(C=CC=C3)=C3/C(C(C=CC=C4)=C4C=C2)=C1CCN(CCCCC5=NNN=N5)CC/1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AT 56

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.88 50

Preparing Stock Solutions for AT 56

The following data is based on the product molecular weight 397.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.03 mL 25.16 mL 50.31 mL
2.5 mM 1.01 mL 5.03 mL 10.06 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
25 mM 0.1 mL 0.5 mL 1.01 mL

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Product Datasheets for AT 56

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for AT 56

References are publications that support the biological activity of the product.

Irikura et al (2009) Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. J.Biol.Chem. 284 7623 PMID: 19131342

If you know of a relevant reference for AT 56, please let us know.

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Keywords: AT 56, AT 56 supplier, AT56, L-PGDS, lipocalin-type, prostaglandin, PG, D, synthase, inhibitors, inhibits, Other, Synthases/Synthetases, 3531, Tocris Bioscience

1 Citation for AT 56

Citations are publications that use Tocris products. Selected citations for AT 56 include:

Jaurena et al (2015) Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Elife 6 7476 PMID: 26101153

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Literature in this Area

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