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Biological Activity for AT 56
AT 56 is an orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki = 75 μM, IC50 = 95 μM). Inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.
Compound Libraries for AT 56
Technical Data for AT 56
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AT 56
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AT 56
The following data is based on the product molecular weight 397.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.03 mL||25.16 mL||50.31 mL|
|2.5 mM||1.01 mL||5.03 mL||10.06 mL|
|5 mM||0.5 mL||2.52 mL||5.03 mL|
|25 mM||0.1 mL||0.5 mL||1.01 mL|
References for AT 56
References are publications that support the biological activity of the product.
Irikura et al (2009) Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. J.Biol.Chem. 284 7623 PMID: 19131342
If you know of a relevant reference for AT 56, please let us know.
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Keywords: AT 56, AT 56 supplier, AT56, L-PGDS, lipocalin-type, prostaglandin, PG, D, synthase, inhibitors, inhibits, Other, Synthases/Synthetases, 3531, Tocris Bioscience
1 Citation for AT 56
Citations are publications that use Tocris products. Selected citations for AT 56 include:
Jaurena et al (2015) Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Elife 6 7476 PMID: 26101153
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Reviews for AT 56
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Literature in this Area
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