AT 56

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Cat.No. 3531 - AT 56 | C25H27N5 | CAS No. 162640-98-4
Description: L-PGDS inhibitor
Chemical Name: 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki = 75 μM, IC50 = 95 μM). Inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.

Technical Data

M. Wt 397.52
Formula C25H27N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 162640-98-4
PubChem ID 11741525
InChI Key LQNGMDUIRLSESZ-UHFFFAOYSA-N
Smiles C2(C=CC=C3)=C3/C(C(C=CC=C4)=C4C=C2)=C1CCN(CCCCC5=NNN=N5)CC/1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.88 50

Preparing Stock Solutions

The following data is based on the product molecular weight 397.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.03 mL 25.16 mL 50.31 mL
2.5 mM 1.01 mL 5.03 mL 10.06 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
25 mM 0.1 mL 0.5 mL 1.01 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Irikura et al (2009) Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. J.Biol.Chem. 284 7623 PMID: 19131342


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Keywords: AT 56, AT 56 supplier, AT56, L-PGDS, lipocalin-type, prostaglandin, PG, D, synthase, inhibitors, inhibits, Other, Synthases/Synthetases, 3531, Tocris Bioscience

1 Citation for AT 56

Citations are publications that use Tocris products. Selected citations for AT 56 include:

Jaurena et al (2015) Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Elife 6 7476 PMID: 26101153


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Literature in this Area

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