Asenapine maleate

Pricing Availability Delivery Time Qty
Cat.No. 3737 - Asenapine maleate | C17H16ClNO.C4H4O4 | CAS No. 85650-56-2
Description: Novel antipsychotic agent
Chemical Name: (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, 5-HT7, D1, D2L, D2S, D3, D4, α1A, α2A, α2B, α2C, H1 and H2 receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.

Compound Libraries

Asenapine maleate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 401.84
Formula C17H16ClNO.C4H4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 85650-56-2
PubChem ID 73416848
InChI Key QGBIWSABMNWWNB-FGYPTBLJSA-N
Smiles CN2C[C@]1([H])C3=C(C=CC=C3)OC4=C(C=C(Cl)C=C4)[C@]([H])1C2.CN6C[C@@]5([H])C7=C(C=CC=C7)OC8=C(C=C(Cl)C=C8)[C@@]([H])5C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.18 100
ethanol 20.09 50

Preparing Stock Solutions

The following data is based on the product molecular weight 401.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Shahid et al (2009) Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J.Psychopharmacol. 23 65 PMID: 18308814

Meltzer et al (2009) Asenapine. Nat.Rev.Drug Discov. 8 843 PMID: 19876039

Marston et al (2009) Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacol. 206 699 PMID:


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1 Citation for Asenapine maleate

Citations are publications that use Tocris products. Selected citations for Asenapine maleate include:

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641


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