AS 1269574

Pricing Availability   Qty
Cat.No. 4177 - AS 1269574 | C13H14BrN3O | CAS No. 330981-72-1
Description: GPR119 receptor agonist
Chemical Name: 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

GPR119 receptor agonist (EC50 = 2.5 μM in HEK293 cells expressing human GPR119). Enhances insulin secretion stimulated by glucose in vivo. Stimulates proglucagon gene promoter actvity. Orally available.

Compound Libraries

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Technical Data

M. Wt 308.17
Formula C13H14BrN3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 330981-72-1
PubChem ID 5332859
InChI Key DUKPGOOUJNUIOI-UHFFFAOYSA-N
Smiles BrC(C=C2)=CC=C2C1=NC(NCCO)=CC(C)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.82 100
ethanol 30.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 308.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.22 mL 32.45 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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References

References are publications that support the biological activity of the product.

Yoshida et al (2010) Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated Ins secretion. Biochem.Biophys.Res.Commun. 400 437 PMID: 20804735

Chepurny et al (2013) Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag. Mol.Endocrinol. 27 1267 PMID: 23798572


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Keywords: AS 1269574, AS 1269574 supplier, AS1269574, Supplier, GPR119, agonist, glucose-dependent, insulin, 4177, Tocris Bioscience

Citations for AS 1269574

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