AS 1269574

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Cat.No. 4177 - AS 1269574 | C13H14BrN3O | CAS No. 330981-72-1
Description: GPR119 receptor agonist
Chemical Name: 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol
Purity: ≥98% (HPLC)

Biological Activity

GPR119 receptor agonist (EC50 = 2.5 μM in HEK293 cells expressing human GPR119). Enhances insulin secretion stimulated by glucose in vivo. Stimulates proglucagon gene promoter actvity. Orally available.

Compound Libraries

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Technical Data

M. Wt 308.17
Formula C13H14BrN3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 330981-72-1
PubChem ID 5332859
Smiles BrC(C=C2)=CC=C2C1=NC(NCCO)=CC(C)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.82 100
ethanol 30.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 308.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.22 mL 32.45 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Yoshida et al (2010) Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem.Biophys.Res.Commun. 400 437 PMID: 20804735

Chepurny et al (2013) Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag. Mol.Endocrinol. 27 1267 PMID: 23798572

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Keywords: AS 1269574, supplier, AS1269574, Supplier, GPR119, agonist, glucose-dependent, insulin, GPR119, GPR119, Tocris Bioscience

Citations for AS 1269574

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GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pathways for AS 1269574


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