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GPR119 receptor agonist (EC50 = 2.5 μM in HEK293 cells expressing human GPR119). Enhances insulin secretion stimulated by glucose in vivo. Stimulates proglucagon gene promoter actvity. Orally available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 308.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.24 mL||16.22 mL||32.45 mL|
|5 mM||0.65 mL||3.24 mL||6.49 mL|
|10 mM||0.32 mL||1.62 mL||3.24 mL|
|50 mM||0.06 mL||0.32 mL||0.65 mL|
References are publications that support the biological activity of the product.
Yoshida et al (2010) Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated Ins secretion. Biochem.Biophys.Res.Commun. 400 437 PMID: 20804735
Chepurny et al (2013) Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag. Mol.Endocrinol. 27 1267 PMID: 23798572
If you know of a relevant reference for AS 1269574, please let us know.
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Keywords: AS 1269574, AS 1269574 supplier, AS1269574, Supplier, GPR119, agonist, glucose-dependent, insulin, 4177, Tocris Bioscience
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