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Description: Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral
Chemical Name: Ethyl 6-Bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl-2-((phenylthio)methyl)-1H-indole-3-carboxylate hydrochloride
Purity: ≥98% (HPLC)

Biological Activity for Arbidol

Arbidol is a broad spectrum antiviral. Displays activity against a range of respiratory and hepatitis viruses including influenza A, B and C, adenovirus, and hepatitis B and C. Increases stability of influenza viral hemagglutinins (HA) and prevents low-pH HA transition so inhibiting viral fusion. Also inhibits SARS-CoV-2 infection in vitro (IC50 = 4.11 μM).

Compound Libraries for Arbidol

Arbidol is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Arbidol

M. Wt 513.88
Formula C22H25BrN2O3S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 131707-23-8
PubChem ID 9958103
Smiles Cl.CCOC(=O)C1=C(CSC2=CC=CC=C2)N(C)C2=CC(Br)=C(O)C(CN(C)C)=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Arbidol

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 51.39 100
DMSO 51.39 100

Preparing Stock Solutions for Arbidol

The following data is based on the product molecular weight 513.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.73 mL 19.46 mL
5 mM 0.39 mL 1.95 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References for Arbidol

References are publications that support the biological activity of the product.

Boriskin et al (2008) Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr.Med.Chem. 15 997 PMID: 18393857

Wang et al (2020) The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 6 28 PMID: 32373347

If you know of a relevant reference for Arbidol, please let us know.

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Citations for Arbidol

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Currently there are no citations for Arbidol. Do you know of a great paper that uses Arbidol from Tocris? Please let us know.

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