AR-R 17779 hydrochloride

Discontinued Product

AR-R 17779 hydrochloride (Cat. No. 3964) has been withdrawn from sale for commercial reasons.
Cat.No. 3964 - AR-R 17779 hydrochloride | C9H14N2O2.HCl | CAS No. 178419-42-6
Description: Selective α7 nAChR agonist
Chemical Name: (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride
Datasheet
Citations (2)
Reviews
Literature (6)

Biological Activity

Selective agonist of α7 nAChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). CNS penetrant after systemic administration.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 218.68
Formula C9H14N2O2.HCl
Storage Desiccate at RT
CAS Number 178419-42-6
PubChem ID 9859263
InChI Key XGLBLUBBDSJBIU-FVGYRXGTSA-N
Smiles O=C(NC3)O[C@@]13CN2CCC1CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Grottick et al (2000) Evidence that nicotinic α7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine. J.Pharmacol.Exp.Ther. 294 1112 PMID: 10945867

Mullen et al (2000) (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor. J.Med.Chem. 43 4045 PMID: 11063601

Huang et al (2010) Activation of presynaptic α7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study. Br.J.Pharmacol. 159 554 PMID: 20105181

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2 Citations for AR-R 17779 hydrochloride

Citations are publications that use Tocris products. Selected citations for AR-R 17779 hydrochloride include:

Cao et al (2019) α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin. Front Immunol 10 1063 PMID: 31143190

Cortes et al (2017) α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis. Sci Rep 7 10645 PMID: 28878260


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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