AR 420626

Pricing Availability   Qty
Description: FFA3 agonist
Chemical Name: N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
Purity: ≥98% (HPLC)

Biological Activity for AR 420626

AR 420626 is a FFA3 agonist (pEC50 = 5.74). Inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. Also suppresses serotonin-induced fecal output in rats.

Compound Libraries for AR 420626

AR 420626 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AR 420626

M. Wt 417.29
Formula C21H18Cl2N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1798310-55-0
PubChem ID 11509934
Smiles CC1=C(C(NC2=C(C=CC(Cl)=C2)Cl)=O)C(C3=C(N1)CCCC3=O)C4=CC=CO4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AR 420626

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.86 50

Preparing Stock Solutions for AR 420626

The following data is based on the product molecular weight 417.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.79 mL 23.96 mL 47.93 mL
2.5 mM 0.96 mL 4.79 mL 9.59 mL
5 mM 0.48 mL 2.4 mL 4.79 mL
25 mM 0.1 mL 0.48 mL 0.96 mL

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References for AR 420626

References are publications that support the biological activity of the product.

Hudson et al (2014) Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 86 200 PMID: 24870406

Kaji et al (2017) Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol.Motil. 30 PMID: 28714277

If you know of a relevant reference for AR 420626, please let us know.

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Citations for AR 420626

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