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Biological Activity for AR 420626
AR 420626 is a FFA3 agonist (pEC50 = 5.74). Inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. Also suppresses serotonin-induced fecal output in rats.
Compound Libraries for AR 420626
Technical Data for AR 420626
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AR 420626
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AR 420626
The following data is based on the product molecular weight 417.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.79 mL||23.96 mL||47.93 mL|
|2.5 mM||0.96 mL||4.79 mL||9.59 mL|
|5 mM||0.48 mL||2.4 mL||4.79 mL|
|25 mM||0.1 mL||0.48 mL||0.96 mL|
References for AR 420626
References are publications that support the biological activity of the product.
Hudson et al (2014) Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 86 200 PMID: 24870406
Kaji et al (2017) Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol.Motil. 30 PMID: 28714277
If you know of a relevant reference for AR 420626, please let us know.
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Citations for AR 420626
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Literature in this Area
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