AR 420626

Pricing Availability Delivery Time Qty
Cat.No. 6163 - AR 420626 | C21H18Cl2N2O3 | CAS No. 1798310-55-0
Description: FFA3 agonist
Chemical Name: N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

FFA3 agonist (pEC50 = 5.74). Inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. Also suppresses serotonin-induced fecal output in rats.

Technical Data

M. Wt 417.29
Formula C21H18Cl2N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1798310-55-0
PubChem ID 11509934
InChI Key BYLWSJCOCFUZDH-UHFFFAOYSA-N
Smiles CC1=C(C(NC2=C(C=CC(Cl)=C2)Cl)=O)C(C3=C(N1)CCCC3=O)C4=CC=CO4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.86 50

Preparing Stock Solutions

The following data is based on the product molecular weight 417.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 11.98 mL 23.96 mL
5 mM 0.48 mL 2.4 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hudson et al (2014) Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 86 200 PMID: 24870406

Kaji et al (2017) Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol.Motil. PMID: 28714277


If you know of a relevant reference for AR 420626, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Free Fatty Acid Receptor Agonists

Keywords: AR 420626, supplier, AR420626, free, fatty, acid, FFAR, FFA3, agonist, agonism, short, chain, SCFA, Free, Fatty, Acid, Receptors, Free, Fatty, Acid, Receptors, Tocris Bioscience

Citations for AR 420626

Citations are publications that use Tocris products.

Currently there are no citations for AR 420626. Do you know of a great paper that uses AR 420626 from Tocris? If so please let us know.

AR 420626 Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used AR 420626?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling