FFA3 agonist (pEC50 = 5.74). Inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. Also suppresses serotonin-induced fecal output in rats.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 417.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.79 mL||23.96 mL||47.93 mL|
|2.5 mM||0.96 mL||4.79 mL||9.59 mL|
|5 mM||0.48 mL||2.4 mL||4.79 mL|
|25 mM||0.1 mL||0.48 mL||0.96 mL|
References are publications that support the biological activity of the product.
Hudson et al (2014) Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 86 200 PMID: 24870406
Kaji et al (2017) Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol.Motil. 30 PMID: 28714277
If you know of a relevant reference for AR 420626, please let us know.
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