APY 29

Pricing Availability Delivery Time Qty
Cat.No. 4865 - APY 29 | C17H16N8 | CAS No. 1216665-49-4
Description: Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity
Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.

Compound Libraries

APY 29 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 332.36
Formula C17H16N8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1216665-49-4
PubChem ID 42627755
InChI Key WJNBSTLIALIIEW-UHFFFAOYSA-N
Smiles C1(NC2=CC(NC=N3)=C3C=C2)=NC=CC(NC4=CC(C5CC5)=NN4)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 16.62 50
DMSO 33.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 332.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.09 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wang et al (2012) Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol. 8 982 PMID: 23086298

Korennykh et al (2009) The unfolded protein response signals through high-order assembly of Ire1. Nature 457 687 PMID: 19079236


If you know of a relevant reference for APY 29, please let us know.

View Related Products by Target

Keywords: APY29 inhibits IRE1a IRE1alpha IRE1α endoribonuclease RNase activates autophosphorylation auto phosphorylation esterases inhibitors activators ER-stress IRE1

Citations for APY 29

Citations are publications that use Tocris products.

Currently there are no citations for APY 29. Do you know of a great paper that uses APY 29 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for APY 29

Protocols

TODO: Add Protocols