APY 29

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Description: Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity
Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity for APY 29

APY 29 is an allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.

Compound Libraries for APY 29

APY 29 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for APY 29

M. Wt 332.36
Formula C17H16N8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1216665-49-4
PubChem ID 42627755
InChI Key WJNBSTLIALIIEW-UHFFFAOYSA-N
Smiles C1(NC2=CC(NC=N3)=C3C=C2)=NC=CC(NC4=CC(C5CC5)=NN4)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for APY 29

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 16.62 50
DMSO 33.24 100

Preparing Stock Solutions for APY 29

The following data is based on the product molecular weight 332.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.09 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for APY 29

Certificate of Analysis / Product Datasheet
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References for APY 29

References are publications that support the biological activity of the product.

Wang et al (2012) Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol. 8 982 PMID: 23086298

Korennykh et al (2009) The unfolded protein response signals through high-order assembly of Ire1. Nature 457 687 PMID: 19079236


If you know of a relevant reference for APY 29, please let us know.

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Keywords: APY 29, APY 29 supplier, APY29, inhibits, IRE1a, IRE1alpha, IRE1α, endoribonuclease, RNase, activates, autophosphorylation, auto, phosphorylation, esterases, inhibitors, activators, ER-stress, IRE1, 4865, Tocris Bioscience

2 Citations for APY 29

Citations are publications that use Tocris products. Selected citations for APY 29 include:

Govindarajan et al (2018) Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun 9 5340 PMID: 30559399

Ju-Ri et al (2020) IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv 6 eaax9914 PMID: 32128399


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
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