Apigenin

Pricing Availability   Qty
Description: Protein kinase inhibitor
Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Apigenin

Apigenin is a protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC50 values are 59.44 and 31.15 μM at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.

Technical Data for Apigenin

M. Wt 270.2
Formula C15H10O5
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 520-36-5
PubChem ID 5280443
InChI Key KZNIFHPLKGYRTM-UHFFFAOYSA-N
Smiles OC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Apigenin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50

Preparing Stock Solutions for Apigenin

The following data is based on the product molecular weight 270.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.4 mL 37.01 mL 74.02 mL
2.5 mM 1.48 mL 7.4 mL 14.8 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
25 mM 0.15 mL 0.74 mL 1.48 mL

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References for Apigenin

References are publications that support the biological activity of the product.

Choi et al (2009) Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells. J.Clin.Biochem.Nutr. 44 260 PMID: 19430615

Jin et al (2009) Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress. Eur.J.Pharmacol. 616 200 PMID: 19549516

Kuo and Yang (1995) Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem.Biophys.Res.Commun. 212 767 PMID: 7626110

Lin et al (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J.Cell.Biochem.Suppl. 28-29 39 PMID: 9589348

Sato et al (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem.Biophys.Res.Commun. 204 578 PMID: 7980517


If you know of a relevant reference for Apigenin, please let us know.

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Keywords: Apigenin, Apigenin supplier, Protein, kinase, inhibitors, inhibits, Kinases, Broad, Spectrum, Kinase, Inhibitors, IRE1, 1227, Tocris Bioscience

1 Citation for Apigenin

Citations are publications that use Tocris products. Selected citations for Apigenin include:

Lim et al (2006) Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells. J Neurosci 42 3260 PMID: 17045795


Do you know of a great paper that uses Apigenin from Tocris? Please let us know.

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