Home / Pharmacology / Enzymes / Kinases / Broad Spectrum Protein Kinase Inhibitors / Broad Spectrum Protein Kinase Inhibitor Inhibitors / Apigenin

Apigenin

Cat. No. 1227 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Protein kinase inhibitor
Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Apigenin

Apigenin is a protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC50 values are 59.44 and 31.15 μM at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.

Technical Data for Apigenin

M. Wt 270.2
Formula C15H10O5
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 520-36-5
PubChem ID 5280443
InChI Key KZNIFHPLKGYRTM-UHFFFAOYSA-N
Smiles OC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Apigenin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50

Preparing Stock Solutions for Apigenin

The following data is based on the product molecular weight 270.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.4 mL 37.01 mL 74.02 mL
2.5 mM 1.48 mL 7.4 mL 14.8 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
25 mM 0.15 mL 0.74 mL 1.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Apigenin

References are publications that support the biological activity of the product.

Choi et al (2009) Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells. J.Clin.Biochem.Nutr. 44 260 PMID: 19430615

Jin et al (2009) Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress. Eur.J.Pharmacol. 616 200 PMID: 19549516

Kuo and Yang (1995) Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem.Biophys.Res.Commun. 212 767 PMID: 7626110

Lin et al (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J.Cell.Biochem.Suppl. 28-29 39 PMID: 9589348

Sato et al (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem.Biophys.Res.Commun. 204 578 PMID: 7980517

If you know of a relevant reference for Apigenin, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Broad Spectrum Protein Kinase Inhibitor Inhibitors

Keywords: Apigenin, Apigenin supplier, Protein, kinase, inhibitors, inhibits, Kinases, Broad, Spectrum, Kinase, Inhibitors, IRE1, 1227, Tocris Bioscience

1 Citation for Apigenin

Citations are publications that use Tocris products. Selected citations for Apigenin include:

Lim et al (2006) Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells. J Neurosci 42 3260 PMID: 17045795

Do you know of a great paper that uses Apigenin from Tocris? Please let us know.

Reviews for Apigenin

There are currently no reviews for this product. Be the first to review Apigenin and earn rewards!

Have you used Apigenin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis