Apigenin

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Cat.No. 1227 - Apigenin | C15H10O5 | CAS No. 520-36-5
Description: Protein kinase inhibitor
Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC50 values are 59.44 and 31.15 μM at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.

Technical Data

M. Wt 270.2
Formula C15H10O5
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 520-36-5
PubChem ID 5280443
InChI Key KZNIFHPLKGYRTM-UHFFFAOYSA-N
Smiles OC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 50 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 270.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 37.01 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Choi et al (2009) Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells. J.Clin.Biochem.Nutr. 44 260 PMID: 19430615

Jin et al (2009) Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress. Eur.J.Pharmacol. 616 200 PMID: 19549516

Kuo and Yang (1995) Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem.Biophys.Res.Commun. 212 767 PMID: 7626110

Lin et al (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J.Cell.Biochem.Suppl. 28-29 39 PMID: 9589348

Sato et al (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem.Biophys.Res.Commun. 204 578 PMID: 7980517


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View all Broad Spectrum Protein Kinase Inhibitor Inhibitors

Keywords: Protein kinase inhibitors inhibits Kinases Broad Spectrum Broad Spectrum Protein Kinase Inhibitors

1 Citation for Apigenin

Citations are publications that use Tocris products. Selected citations for Apigenin include:

Lim et al (2006) Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells. J Neurosci 42 3260 PMID: 17045795


Do you know of a great paper that uses Apigenin from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for Apigenin

Protocols

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