Apigenin

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Cat.No. 1227 - Apigenin | C15H10O5 | CAS No. 520-36-5
Description: Protein kinase inhibitor
Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity

Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC50 values are 59.44 and 31.15 μM at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.

Technical Data

M. Wt 270.2
Formula C15H10O5
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 520-36-5
PubChem ID 5280443
InChI Key KZNIFHPLKGYRTM-UHFFFAOYSA-N
Smiles OC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 50 mM in DMSO

References

References are publications that support the biological activity of the product.

Choi et al (2009) Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells. J.Clin.Biochem.Nutr. 44 260 PMID: 19430615

Jin et al (2009) Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress. Eur.J.Pharmacol. 616 200 PMID: 19549516

Kuo and Yang (1995) Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem.Biophys.Res.Commun. 212 767 PMID: 7626110

Lin et al (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J.Cell.Biochem.Suppl. 28-29 39 PMID: 9589348

Sato et al (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem.Biophys.Res.Commun. 204 578 PMID: 7980517


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1 Citation for Apigenin

Citations are publications that use Tocris products. Selected citations for Apigenin include:

Lim et al (2006) Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells. J Neurosci 42 3260 PMID: 17045795


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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Kinases Product Listing

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