Apelin-17 (human, bovine)

Pricing Availability   Qty
Description: Endogenous apelin agonist
Alternative Names: K17F,Prepro-61-77-Apelin
Purity: ≥95% (HPLC)
Citations (1)

Biological Activity for Apelin-17 (human, bovine)

Apelin-17 (human, bovine) is an endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).

Technical Data for Apelin-17 (human, bovine)

M. Wt 2138.56
Formula C96H156N34O20S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 217082-57-0
PubChem ID 16130452
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Apelin-17 (human, bovine)

Solubility Soluble to 1.20 mg/ml in water

Product Datasheets for Apelin-17 (human, bovine)

Certificate of Analysis / Product Datasheet
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References for Apelin-17 (human, bovine)

References are publications that support the biological activity of the product.

Medhurst et al (2003) Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J.Neurochem. 84 1162 PMID: 12603839

Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comms. 251 471

De Mota et al (2004) Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc.Natl.Acad.Sci. USA 101 10464

If you know of a relevant reference for Apelin-17 (human, bovine), please let us know.

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Keywords: Apelin-17 (human, bovine), Apelin-17 (human, bovine) supplier, Endogenous, APJ, receptor, agonists, Receptors, Apelin, adipokines, K17F, Prepro-61-77-Apelin, 3007, Tocris Bioscience

1 Citation for Apelin-17 (human, bovine)

Citations are publications that use Tocris products. Selected citations for Apelin-17 (human, bovine) include:

Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888

Do you know of a great paper that uses Apelin-17 (human, bovine) from Tocris? Please let us know.

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