Apelin-17 (human, bovine)

Pricing Availability Delivery Time Qty
Cat.No. 3007 - Apelin-17 (human, bovine) | Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe | CAS No. 217082-57-0
Description: Endogenous APJ receptor agonist
Alternative Names: K17F, Prepro-61-77-Apelin
Datasheet
Citations
Literature

Biological Activity

Endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).

Technical Data

M. Wt 2138.56
Formula C96H156N34O20S
Sequence KFRRQRPRLSHKGPMPF
Storage Desiccate at -20°C
CAS Number 217082-57-0
PubChem ID 16130452
InChI Key SVWSKJCJNAIKNH-MJZUAXFLSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1.20 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2138.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.47 mL 2.34 mL 4.68 mL
5 mM 0.09 mL 0.47 mL 0.94 mL
10 mM 0.05 mL 0.23 mL 0.47 mL
50 mM 0.01 mL 0.05 mL 0.09 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Medhurst et al (2003) Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J.Neurochem. 84 1162 PMID: 12603839

Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comms. 251 471 PMID:

De Mota et al (2004) Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc.Natl.Acad.Sci. USA 101 10464 PMID:


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Keywords: Apelin-17 (human, bovine), supplier, Endogenous, APJ, receptor, agonists, Receptors, Apelin, adipokines, K17F, Prepro-61-77-Apelin, Apelin, Receptors, Tocris Bioscience

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Pathways for Apelin-17 (human, bovine)

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