ANR 94

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Cat.No. 3937 - ANR 94 | C9H13N5O | CAS No. 634924-89-3
Description: Adenosine A2A antagonist
Chemical Name: 8-Ethoxy-9-ethyl-9H-purin-6-amine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Adenosine A2A receptor (AA2AR) antagonist (Ki values are 643 and 46 nM for rat and human AA2ARs respectively). Most active AA2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.

Compound Libraries

ANR 94 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 207.23
Formula C9H13N5O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 634924-89-3
PubChem ID 11805896
InChI Key QUGDTMONBLMLLD-UHFFFAOYSA-N
Smiles CCN2C1=NC=NC(N)=C1N=C2OCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.36 50
ethanol 20.72 100

Preparing Stock Solutions

The following data is based on the product molecular weight 207.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.83 mL 24.13 mL 48.26 mL
5 mM 0.97 mL 4.83 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.83 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Pinna et al (2010) A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology 58 613 PMID: 19951715

Volpini et al (2010) Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. Chem.Med.Chem. 4 1010 PMID:


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1 Citation for ANR 94

Citations are publications that use Tocris products. Selected citations for ANR 94 include:

Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Circulation 14 201 PMID: 26597723


Do you know of a great paper that uses ANR 94 from Tocris? If so please let us know.

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Literature in this Area

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Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

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Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for ANR 94

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