ANR 94

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Cat.No. 3937 - ANR 94 | C9H13N5O | CAS No. 634924-89-3
Description: Adenosine A2A antagonist
Chemical Name: 8-Ethoxy-9-ethyl-9H-purin-6-amine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (6)

Biological Activity for ANR 94

ANR 94 is an adenosine A2A receptor (AA2AR) antagonist (Ki values are 643 and 46 nM for rat and human AA2ARs respectively). Most active AA2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.

Compound Libraries for ANR 94

ANR 94 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ANR 94

M. Wt 207.23
Formula C9H13N5O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 634924-89-3
PubChem ID 11805896
InChI Key QUGDTMONBLMLLD-UHFFFAOYSA-N
Smiles CCN2C1=NC=NC(N)=C1N=C2OCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ANR 94

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.36 50
ethanol 20.72 100

Preparing Stock Solutions for ANR 94

The following data is based on the product molecular weight 207.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.83 mL 24.13 mL 48.26 mL
5 mM 0.97 mL 4.83 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.83 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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References for ANR 94

References are publications that support the biological activity of the product.

Pinna et al (2010) A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology 58 613 PMID: 19951715

Volpini et al (2010) Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. Chem.Med.Chem. 4 1010 PMID: 19343763


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Keywords: ANR 94, ANR 94 supplier, ANR94, adenosine, A2A, receptor, antagonist, AA2AR, antagonists, antiparkinsonian, activity, Adenosine, Receptors, 3937, Tocris Bioscience

1 Citation for ANR 94

Citations are publications that use Tocris products. Selected citations for ANR 94 include:

Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Circulation 14 201 PMID: 26597723


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Reviews for ANR 94

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Literature in this Area

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