Nootropic, with modulatory actions through allosteric potentiation of AMPA specific receptors, reduction of glutamate receptor desensitization and potentiation of metabotropic glutamate receptor activity. Anxiolytic following systemic administration.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 219.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.56 mL||22.81 mL||45.61 mL|
|5 mM||0.91 mL||4.56 mL||9.12 mL|
|10 mM||0.46 mL||2.28 mL||4.56 mL|
|50 mM||0.09 mL||0.46 mL||0.91 mL|
References are publications that support the products' biological activity.
Isaacson and Nicholl (1991) Aniracetam reduces glutamate receptor desensitisation and slows the decay of fast excitatory synaptic currents in the hippocampus. Proc.Natl.Acad.Sci.U.S.A. 88 10936 PMID: 1660156
Ito et al (1990) Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. J.Physiol. 424 553 PMID: 1975272
Nakamura and Kurasawa (2001) Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur.J.Pharmacol. 420 33 PMID: 11412837
If you know of a relevant reference for Aniracetam, please let us know.
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Keywords: Aniracetam, supplier, Desensitization, inhibitors, inhibits, AMPA, kainate, Glutamate, Receptors, iGluR, Ionotropic, allosteric, modulators, potentiators, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
Citations for Aniracetam
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