Amyloid β-peptide (25-35) (human)

Pricing Availability Delivery Time Qty
Cat.No. 1429 - Amyloid b-peptide (25-35) (human) | Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met | CAS No. 131602-53-4
Description: Human amyloid β-protein fragment functionally required for neurotoxicity
Datasheet
Citations (1)
Literature

Biological Activity

Fragment of human amyloid β-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.

Technical Data

M. Wt 1060.27
Formula C45H81N13O14S
Sequence GSNKGAIIGLM
Storage Desiccate at -20°C
CAS Number 131602-53-4
PubChem ID 10843733
InChI Key WIHBNMPFWRHGDF-SLVFWPMISA-N
Smiles [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.50 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1060.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.94 mL 4.72 mL 9.43 mL
5 mM 0.19 mL 0.94 mL 1.89 mL
10 mM 0.09 mL 0.47 mL 0.94 mL
50 mM 0.02 mL 0.09 mL 0.19 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Rush et al (1992) Intracerebral β-amyloid(25-35) produces tissue damage: is it neurotoxic? Neurobiol.Aging 13 591 PMID: 1281289

Schenk et al (1995) Therapeutic approaches related to amyloid-β peptide and Alzheimer's Disease J.Med.Chem. 38 4141 PMID: 7473539

Yankner et al (1990) Neurotrophic and neurotoxic effects of amyoid β protein: reversal by tachykinin neuropeptides. Science 250 279 PMID: 2218531


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1 Citation for Amyloid β-peptide (25-35) (human)

Citations are publications that use Tocris products. Selected citations for Amyloid β-peptide (25-35) (human) include:

Ostrovskaya et al (2014) Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J.Biomed.Sci. 21 74 PMID: 25096780


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