Amthamine dihydrobromide

Pricing Availability   Qty
Description: Highly selective standard H2 agonist
Chemical Name: 2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide
Purity: ≥99% (HPLC)
Citations (4)
Literature (1)

Biological Activity for Amthamine dihydrobromide

Amthamine dihydrobromide is a highly selective H2 agonist, slightly more potent than histamine itself. Only a weak antagonist at H3 and has no activity at H1 receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.

Technical Data for Amthamine dihydrobromide

M. Wt 319.06
Formula C6H11N3S.2HBr
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 142457-00-9
PubChem ID 16218912
Smiles Br.Br.CC1=C(CCN)SC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Amthamine dihydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
water 31.91 100

Preparing Stock Solutions for Amthamine dihydrobromide

The following data is based on the product molecular weight 319.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.67 mL 31.34 mL
5 mM 0.63 mL 3.13 mL 6.27 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets for Amthamine dihydrobromide

References for Amthamine dihydrobromide

References are publications that support the biological activity of the product.

Coruzzi et al (1993) The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion. Naunyn Schmiedebergs Arch.Pharmacol. 348 77 PMID: 8377843

Eriks et al (1992) Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole. J.Med.Chem. 35 3239 PMID: 1507209

Jarajapu et al (2006) Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP. Eur.J.Pharmacol. 547 116 PMID: 16920098

Poli et al (1993) In vitro cardiac pharmacology of the new histamine H2 receptor agonist amthamine; comparisons with histamine and dimaprit. Agents Actions 40 44 PMID: 8147269

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Keywords: Amthamine dihydrobromide, Amthamine dihydrobromide supplier, selective, H2, agonists, Receptors, Histamine, histaminergic, 0668, Tocris Bioscience

4 Citations for Amthamine dihydrobromide

Citations are publications that use Tocris products. Selected citations for Amthamine dihydrobromide include:

Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809

Chigaev et al (2011) Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. J Biol Chem 286 20375 PMID: 21515675

Saligrama et al (2014) Histamine H2 receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis. FASEB J 28 1898 PMID: 24371118

Copsel et al (2011) Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation. J Biol Chem 286 6979 PMID: 21205825

Do you know of a great paper that uses Amthamine dihydrobromide from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.