Amisulpride

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Cat.No. 2132 - Amisulpride | C17H27N3O4S | CAS No. 71675-85-9
Description: Selective D2 and D3 antagonist; atypical antipsychotic
Alternative Names: DAN 2163
Chemical Name: 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (5)

Biological Activity

Potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.

Technical Data

M. Wt 369.48
Formula C17H27N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 71675-85-9
PubChem ID 2159
InChI Key NTJOBXMMWNYJFB-UHFFFAOYSA-N
Smiles CCN1CCCC1CNC(=O)C1=C(OC)C=C(N)C(=C1)S(=O)(=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 9.24 25 with gentle warming
DMSO 18.47 50

Preparing Stock Solutions

The following data is based on the product molecular weight 369.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.41 mL 27.07 mL 54.13 mL
2.5 mM 1.08 mL 5.41 mL 10.83 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Perrault et al (1997) Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 DA receptor antagonist activity and limbic selectivity. J.Pharmacol.Exp.Ther. 280 73 PMID: 8996184

Schoemaker et al (1997) Neurochemical characteristics of amisulpride, an atypical DA D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J.Pharmacol.Exp.Ther. 280 83 PMID: 8996185

Moller (2003) Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog.Neuro-Psychopharm.Biol.Psychiat. 27 1101


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Keywords: Amisulpride, Amisulpride supplier, Selective, D2/D3, receptor, antagonists, atypical, antipsychotic, agent, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, DAN2163, DAN, 2163, Non-selective, 2132, Tocris Bioscience

2 Citations for Amisulpride

Citations are publications that use Tocris products. Selected citations for Amisulpride include:

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643

Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395 PMID: 21966518


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