Pricing Availability   Qty
Description: Selective D2 and D3 antagonist; atypical antipsychotic
Alternative Names: DAN 2163
Chemical Name: 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for Amisulpride

Amisulpride is a potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.

Technical Data for Amisulpride

M. Wt 369.48
Formula C17H27N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 71675-85-9
PubChem ID 2159
Smiles CCN1CCCC1CNC(=O)C1=C(OC)C=C(N)C(=C1)S(=O)(=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Amisulpride

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 9.24 25 with gentle warming
DMSO 18.47 50

Preparing Stock Solutions for Amisulpride

The following data is based on the product molecular weight 369.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.41 mL 27.07 mL 54.13 mL
2.5 mM 1.08 mL 5.41 mL 10.83 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

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Product Datasheets for Amisulpride

Certificate of Analysis / Product Datasheet
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References for Amisulpride

References are publications that support the biological activity of the product.

Perrault et al (1997) Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 DA receptor antagonist activity and limbic selectivity. J.Pharmacol.Exp.Ther. 280 73 PMID: 8996184

Schoemaker et al (1997) Neurochemical characteristics of amisulpride, an atypical DA D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J.Pharmacol.Exp.Ther. 280 83 PMID: 8996185

Moller (2003) Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog.Neuro-Psychopharm.Biol.Psychiat. 27 1101

If you know of a relevant reference for Amisulpride, please let us know.

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Keywords: Amisulpride, Amisulpride supplier, Selective, D2/D3, receptor, antagonists, atypical, antipsychotic, agent, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, DAN2163, DAN, 2163, Non-selective, 2132, Tocris Bioscience

2 Citations for Amisulpride

Citations are publications that use Tocris products. Selected citations for Amisulpride include:

Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395 PMID: 21966518

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643

Do you know of a great paper that uses Amisulpride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.