Broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 681.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.47 mL||7.33 mL||14.67 mL|
|5 mM||0.29 mL||1.47 mL||2.93 mL|
|10 mM||0.15 mL||0.73 mL||1.47 mL|
|50 mM||0.03 mL||0.15 mL||0.29 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Antzelevitch et al (2004) Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110 904 PMID: 15302796
di Matola et al (2000) Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism. J.Clin.Endocrin.Metab. 85 4323 PMID: 11095475
Balgi et al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124 PMID: 19771169
Han et al (2009) Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 4 7155 PMID: 19774075
If you know of a relevant reference for Amiodarone hydrochloride, please let us know.
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Keywords: Amiodarone hydrochloride, supplier, ion, channels, antagonists, blockers, INa, ICa, IKr, IKs, antiarrhythmic, class, III, Other, Channel, Modulators, Autophagy, Stem, Cell, Proliferation, Other, Channel, Modulators, Tocris Bioscience
1 Citation for Amiodarone hydrochloride
Citations are publications that use Tocris products. Selected citations for Amiodarone hydrochloride include:
Turker et al (2013) Amiodarone inhibits apamin-sensitive potassium currents. PLoS One 8 e70450 PMID: 23922993
Do you know of a great paper that uses Amiodarone hydrochloride from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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