Amiodarone hydrochloride

Pricing Availability   Qty
Cat.No. 4095 - Amiodarone hydrochloride | C25H29I2NO3.HCl | CAS No. 19774-82-4
Description: Broad spectrum ion channel blocker; antiarrhythmic
Chemical Name: 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations.

Compound Libraries

Amiodarone hydrochloride is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 681.77
Formula C25H29I2NO3.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 19774-82-4
PubChem ID 29770
InChI Key ITPDYQOUSLNIHG-UHFFFAOYSA-N
Smiles CCCCC2=C(C(C3=CC(I)=C(OCCN(CC)CC)C(I)=C3)=O)C1=CC=CC=C1O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.64 20

Preparing Stock Solutions

The following data is based on the product molecular weight 681.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 7.33 mL 36.67 mL 73.34 mL
1 mM 1.47 mL 7.33 mL 14.67 mL
2 mM 0.73 mL 3.67 mL 7.33 mL
10 mM 0.15 mL 0.73 mL 1.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Antzelevitch et al (2004) Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110 904 PMID: 15302796

di Matola et al (2000) Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism. J.Clin.Endocrin.Metab. 85 4323 PMID: 11095475

Balgi et al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124 PMID: 19771169

Han et al (2009) Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 4 7155 PMID: 19774075


If you know of a relevant reference for Amiodarone hydrochloride, please let us know.

Keywords: Amiodarone hydrochloride, Amiodarone hydrochloride supplier, ion, channels, antagonists, blockers, INa, ICa, IKr, IKs, antiarrhythmic, class, III, Other, Channel, Modulators, Autophagy, Stem, Cell, Proliferation, 4095, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Amiodarone hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

1 Citation for Amiodarone hydrochloride

Citations are publications that use Tocris products. Selected citations for Amiodarone hydrochloride include:

Turker et al (2013) Amiodarone inhibits apamin-sensitive potassium currents. PLoS One 8 e70450 PMID: 23922993


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Literature in this Area

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