Amiodarone hydrochloride

Discontinued Product

Amiodarone hydrochloride (Cat. No. 4095) has been withdrawn from sale for commercial reasons.
Description: Broad spectrum ion channel blocker; antiarrhythmic
Chemical Name: 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
Purity: ≥99% (HPLC)
Citations (3)

Biological Activity for Amiodarone hydrochloride

Amiodarone hydrochloride is a broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations. Amiodarone depolarizes the resting membrane potential of the triple-negative breast cancer (TNBC) cells and decreases cell migration.

Technical Data for Amiodarone hydrochloride

M. Wt 681.77
Formula C25H29I2NO3.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 19774-82-4
PubChem ID 29770
Smiles CCCCC2=C(C(C3=CC(I)=C(OCCN(CC)CC)C(I)=C3)=O)C1=CC=CC=C1O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Amiodarone hydrochloride

Certificate of Analysis / Product Datasheet
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References for Amiodarone hydrochloride

References are publications that support the biological activity of the product.

Antzelevitch et al (2004) Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110 904 PMID: 15302796

di Matola et al (2000) Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism. J.Clin.Endocrin.Metab. 85 4323 PMID: 11095475

Balgi et al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124 PMID: 19771169

Han et al (2009) Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not DA neurons. PLoS One. 4 7155 PMID: 19774075

Payne et al (2021) Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer. EBioMedicine 75 103767 PMID: 34933180

Keywords: Amiodarone hydrochloride, Amiodarone hydrochloride supplier, ion, channels, antagonists, blockers, INa, ICa, IKr, IKs, antiarrhythmic, class, III, promotes, mitochondrial, fragmentation, Other, Channel, Modulators, Autophagy, Stem, Cell, Proliferation, 4095, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Amiodarone hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to

3 Citations for Amiodarone hydrochloride

Citations are publications that use Tocris products. Selected citations for Amiodarone hydrochloride include:

Roland C et al (2013) The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing. Mol Inform 32 47-63 PMID: 27481023

Turker et al (2013) Amiodarone inhibits apamin-sensitive potassium currents. PLoS One 8 e70450 PMID: 23922993

Payne et al (2021) Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer. EBioMedicine 75 103767 PMID: 34933180

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