Discontinued Product

Aminopotentidine (Cat. No. 0721) has been withdrawn from sale for commercial reasons.
Description: H2 antagonist
Chemical Name: 4-Amino-N-[2-[[(cyanoamino)[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]imino]methyl]amino]ethyl]benzamide
Purity: ≥97% (HPLC)
Literature (1)

Biological Activity for Aminopotentidine

Aminopotentidine is a H2 antagonist (KB values are 220 and 280 nM at human and guinea pig H2 receptors respectively) and precursor for the synthesis of the [125I]-iodo derivative.

Technical Data for Aminopotentidine

M. Wt 477.6
Formula C26H35N7O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 140873-26-3
PubChem ID 164435

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Aminopotentidine

Certificate of Analysis / Product Datasheet
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References for Aminopotentidine

References are publications that support the biological activity of the product.

Hirschfield et al (1992) Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor. J.Med.Chem. 35 2231 PMID: 1613748

Ruat et al (1990) Reversible and irreversible labeling and autoradiographic localisation of the cerebral histamine H2 receptor using [125I]iodinated probes. Proc.Natl.Acad.Sci.USA 87 1658 PMID: 2308927

Xie et al (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorg.Med.Chem.Lett. 16 3886 PMID: 16730977

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Keywords: Aminopotentidine, Aminopotentidine supplier, H2, antagonists, Receptors, Histamine, histaminergic, 0721, Tocris Bioscience

Citations for Aminopotentidine

Citations are publications that use Tocris products.

Currently there are no citations for Aminopotentidine.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.