Ambuic Acid

Discontinued Product

Ambuic Acid (Cat. No. 6547) has been withdrawn from sale for commercial reasons.
Description: Quorum sensing inhibitor; antibacterial
Chemical Name: (2E)-4-[(1R,5R,6R)-3-(1E)-1-Hepten-1-yl-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methyl-2-butenoic acid
Purity: ≥95% (HPLC)

Biological Activity for Ambuic Acid

Quorum sensing inhibitor. Inhibits auto-inducing peptide (AIP) signal biosynthesis in MRSA (IC50 = 2.5 μM). Reduces MRSA-induced abcess formation in rats. Exhibits activity against pathogenic Gram-positive bacteria but not commensal bacteria.

Technical Data for Ambuic Acid

M. Wt 350.41
Formula C19H26O6
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 340774-69-8
PubChem ID 11152290
Smiles CCCCC/C=C/C1=C([C@H]([C@H]2O[C@]2(C1=O)C/C=C(C(O)=O)\C)O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Ambuic Acid

References are publications that support the biological activity of the product.

Todd et al (2017) Signal biosynthesis inhibition with ambuic acid as a strategy to target antibiotic-resistant infections. Antimicrob.Agents Chemother. 61 e00263-17 PMID: 28607020

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Keywords: Ambuic Acid, Ambuic Acid supplier, quorum, sensing, inhibitors, inhibits, antibacterial, auto-inducing, peptide, AIP, signal, biosynthesis, MRSA, methicillin, meticillin, resistant, Staphylococcus, aureus, Antibiotics, 6547, Tocris Bioscience

Citations for Ambuic Acid

Citations are publications that use Tocris products.

Currently there are no citations for Ambuic Acid.

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