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Quorum sensing inhibitor. Inhibits auto-inducing peptide (AIP) signal biosynthesis in MRSA (IC50 = 2.5 μM). Reduces MRSA-induced abcess formation in rats. Exhibits activity against pathogenic Gram-positive bacteria but not commensal bacteria.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 350.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.03 mM||95.13 mL||475.63 mL||951.27 mL|
|0.15 mM||19.03 mL||95.13 mL||190.25 mL|
|0.3 mM||9.51 mL||47.56 mL||95.13 mL|
|1.5 mM||1.9 mL||9.51 mL||19.03 mL|
References are publications that support the biological activity of the product.
Todd et al (2017) Signal biosynthesis inhibition with ambuic acid as a strategy to target antibiotic-resistant infections. Antimicrob.Agents Chemother. 61 e00263-17 PMID: 28607020
If you know of a relevant reference for Ambuic Acid, please let us know.
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Keywords: Ambuic Acid, Ambuic Acid supplier, quorum, sensing, inhibitors, inhibits, antibacterial, auto-inducing, peptide, AIP, signal, biosynthesis, MRSA, methicillin, meticillin, resistant, Staphylococcus, aureus, Antibiotics, 6547, Tocris Bioscience
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