Ambuic Acid

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Cat.No. 6547 - Ambuic Acid | C19H26O6 | CAS No. 340774-69-8
Description: Quorum sensing inhibitor; antibacterial
Chemical Name: (2E)-4-[(1R,5R,6R)-3-(1E)-1-Hepten-1-yl-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methyl-2-butenoic acid
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity

Quorum sensing inhibitor. Inhibits auto-inducing peptide (AIP) signal biosynthesis in MRSA (IC50 = 2.5 μM). Reduces MRSA-induced abcess formation in rats. Exhibits activity against pathogenic Gram-positive bacteria but not commensal bacteria.

Technical Data

M. Wt 350.41
Formula C19H26O6
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 340774-69-8
PubChem ID 11152290
Smiles CCCCC/C=C/C1=C([C@H]([C@H]2O[C@]2(C1=O)C/C=C(C(O)=O)\C)O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 1 3
ethanol 1 3

Preparing Stock Solutions

The following data is based on the product molecular weight 350.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.03 mM 95.13 mL 475.63 mL 951.27 mL
0.15 mM 19.03 mL 95.13 mL 190.25 mL
0.3 mM 9.51 mL 47.56 mL 95.13 mL
1.5 mM 1.9 mL 9.51 mL 19.03 mL

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References are publications that support the biological activity of the product.

Todd et al (2017) Signal biosynthesis inhibition with ambuic acid as a strategy to target antibiotic-resistant infections. Antimicrob.Agents Chemother. 61 e00263-17 PMID: 28607020

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