Ambuic Acid

Discontinued Product

Ambuic Acid (Cat. No. 6547) has been withdrawn from sale for commercial reasons.
Cat.No. 6547 - Ambuic Acid | C19H26O6 | CAS No. 340774-69-8
Description: Quorum sensing inhibitor; antibacterial
Chemical Name: (2E)-4-[(1R,5R,6R)-3-(1E)-1-Hepten-1-yl-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methyl-2-butenoic acid
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Quorum sensing inhibitor. Inhibits auto-inducing peptide (AIP) signal biosynthesis in MRSA (IC50 = 2.5 μM). Reduces MRSA-induced abcess formation in rats. Exhibits activity against pathogenic Gram-positive bacteria but not commensal bacteria.

Technical Data

M. Wt 350.41
Formula C19H26O6
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 340774-69-8
PubChem ID 11152290
InChI Key UDSQZJMGPSRCEM-HDKVZZTHSA-N
Smiles CCCCC/C=C/C1=C([C@H]([C@H]2O[C@]2(C1=O)C/C=C(C(O)=O)\C)O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Todd et al (2017) Signal biosynthesis inhibition with ambuic acid as a strategy to target antibiotic-resistant infections. Antimicrob.Agents Chemother. 61 e00263-17 PMID: 28607020

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Keywords: Ambuic Acid, Ambuic Acid supplier, quorum, sensing, inhibitors, inhibits, antibacterial, auto-inducing, peptide, AIP, signal, biosynthesis, MRSA, methicillin, meticillin, resistant, Staphylococcus, aureus, Antibiotics, 6547, Tocris Bioscience

Citations for Ambuic Acid

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Literature in this Area

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