Ambenonium dichloride

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Description: Cholinesterase inhibitor
Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride
Purity: ≥99%
Citations (2)
Literature (1)

Biological Activity for Ambenonium dichloride

Ambenonium dichloride is an extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).

Technical Data for Ambenonium dichloride

M. Wt 608.48
Formula C28H42Cl4N4O2
Storage Store at RT
Purity ≥99%
CAS Number 115-79-7
PubChem ID 8288
Smiles [Cl-].[Cl-].CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=C(Cl)C=CC=C1)CC1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ambenonium dichloride

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for Ambenonium dichloride

The following data is based on the product molecular weight 608.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.22 mL 16.43 mL
5 mM 0.33 mL 1.64 mL 3.29 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets for Ambenonium dichloride

References for Ambenonium dichloride

References are publications that support the biological activity of the product.

Bolognesi et al (2003) Design, synthesis and biological evaluation of amben. derivatives as AChE inhibitors. Farmaco 58 917 PMID: 13679187

Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937 PMID: 1588924

Lands et al (1958) An investigation of the structure-activity correlations within a series of amben. analogs. J.Pharmacol.Exp.Ther. 123 121 PMID: 13550066

Web (1965) Affinity for benzoquinonium, and amben. derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172 PMID: 5833399

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Keywords: Ambenonium dichloride, Ambenonium dichloride supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Non-selective, Muscarinics, Cholinesterases, 0388, Tocris Bioscience

2 Citations for Ambenonium dichloride

Citations are publications that use Tocris products. Selected citations for Ambenonium dichloride include:

Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. Int J Mol Sci 112 8124 PMID: 26080439

Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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