Ambenonium dichloride

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Cat.No. 0388 - Ambenonium dichloride | C28H42Cl4N4O2 | CAS No. 115-79-7
Description: Cholinesterase inhibitor
Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride
Purity: ≥99%
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).

Technical Data

M. Wt 608.48
Formula C28H42Cl4N4O2
Storage Store at RT
Purity ≥99%
CAS Number 115-79-7
PubChem ID 8288
InChI Key DXUUXWKFVDVHIK-UHFFFAOYSA-N
Smiles [Cl-].[Cl-].CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=C(Cl)C=CC=C1)CC1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 608.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.22 mL 16.43 mL
5 mM 0.33 mL 1.64 mL 3.29 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bolognesi et al (2003) Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. Farmaco 58 917 PMID: 13679187

Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937 PMID: 1588924

Lands et al (1958) An investigation of the structure-activity correlations within a series of ambenonium analogs. J.Pharmacol.Exp.Ther. 123 121 PMID: 13550066

Web (1965) Affinity for benzoquinonium, and ambenonium derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172 PMID: 5833399


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Keywords: Ambenonium dichloride, supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Non-selective, Muscarinics, Cholinesterases, Cholinesterases, Tocris Bioscience

2 Citations for Ambenonium dichloride

Citations are publications that use Tocris products. Selected citations for Ambenonium dichloride include:

Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Int J Mol Sci 112 8124 PMID: 26080439

Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263


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