You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 100 mM in water|
References are publications that support the biological activity of the product.
Bolognesi et al (2003) Design, synthesis and biological evaluation of amben. derivatives as AChE inhibitors. Farmaco 58 917 PMID: 13679187
Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937 PMID: 1588924
Lands et al (1958) An investigation of the structure-activity correlations within a series of amben. analogs. J.Pharmacol.Exp.Ther. 123 121 PMID: 13550066
Web (1965) Affinity for benzoquinonium, and amben. derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172 PMID: 5833399
If you know of a relevant reference for Ambenonium dichloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Ambenonium dichloride, Ambenonium dichloride supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Non-selective, Muscarinics, Cholinesterases, 0388, Tocris Bioscience
2 Citations for Ambenonium dichloride
Citations are publications that use Tocris products. Selected citations for Ambenonium dichloride include:
Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263
Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. Int J Mol Sci 112 8124 PMID: 26080439
Do you know of a great paper that uses Ambenonium dichloride from Tocris? Please let us know.
Reviews for Ambenonium dichloride
There are currently no reviews for this product. Be the first to review Ambenonium dichloride and earn rewards!
Have you used Ambenonium dichloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.