Ambenonium dichloride

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Cholinesterase inhibitor
Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride
Purity: ≥99%
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity for Ambenonium dichloride

Ambenonium dichloride is an extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).

Technical Data for Ambenonium dichloride

M. Wt 608.48
Formula C28H42Cl4N4O2
Storage Store at RT
Purity ≥99%
CAS Number 115-79-7
PubChem ID 8288
InChI Key DXUUXWKFVDVHIK-UHFFFAOYSA-N
Smiles [Cl-].[Cl-].CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=C(Cl)C=CC=C1)CC1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ambenonium dichloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for Ambenonium dichloride

The following data is based on the product molecular weight 608.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.22 mL 16.43 mL
5 mM 0.33 mL 1.64 mL 3.29 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Ambenonium dichloride

References for Ambenonium dichloride

References are publications that support the biological activity of the product.

Bolognesi et al (2003) Design, synthesis and biological evaluation of amben. derivatives as AChE inhibitors. Farmaco 58 917 PMID: 13679187

Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937 PMID: 1588924

Lands et al (1958) An investigation of the structure-activity correlations within a series of amben. analogs. J.Pharmacol.Exp.Ther. 123 121 PMID: 13550066

Web (1965) Affinity for benzoquinonium, and amben. derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172 PMID: 5833399


If you know of a relevant reference for Ambenonium dichloride, please let us know.

View Related Products by Product Action

View all Cholinesterase Inhibitors

Keywords: Ambenonium dichloride, Ambenonium dichloride supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Non-selective, Muscarinics, Cholinesterases, 0388, Tocris Bioscience

2 Citations for Ambenonium dichloride

Citations are publications that use Tocris products. Selected citations for Ambenonium dichloride include:

Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. Int J Mol Sci 112 8124 PMID: 26080439

Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263


Do you know of a great paper that uses Ambenonium dichloride from Tocris? Please let us know.

Reviews for Ambenonium dichloride

There are currently no reviews for this product. Be the first to review Ambenonium dichloride and earn rewards!

Have you used Ambenonium dichloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.