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Submit ReviewAmbenonium dichloride
Description: Cholinesterase inhibitor
Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride
Purity: ≥99%
Biological Activity for Ambenonium dichloride
Ambenonium dichloride is an extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).
Technical Data for Ambenonium dichloride
| M. Wt | 608.48 |
| Formula | C28H42Cl4N4O2 |
| Storage | Store at RT |
| Purity | ≥99% |
| CAS Number | 115-79-7 |
| PubChem ID | 8288 |
| InChI Key | DXUUXWKFVDVHIK-UHFFFAOYSA-N |
| Smiles | [Cl-].[Cl-].CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=C(Cl)C=CC=C1)CC1=C(Cl)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ambenonium dichloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions for Ambenonium dichloride
The following data is based on the product molecular weight 608.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.64 mL | 8.22 mL | 16.43 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.29 mL |
| 10 mM | 0.16 mL | 0.82 mL | 1.64 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
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Product Datasheets for Ambenonium dichloride
References for Ambenonium dichloride
References are publications that support the biological activity of the product.
Bolognesi et al (2003) Design, synthesis and biological evaluation of amben. derivatives as AChE inhibitors. Farmaco 58 917 PMID: 13679187
Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937 PMID: 1588924
Lands et al (1958) An investigation of the structure-activity correlations within a series of amben. analogs. J.Pharmacol.Exp.Ther. 123 121 PMID: 13550066
Web (1965) Affinity for benzoquinonium, and amben. derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172 PMID: 5833399
If you know of a relevant reference for Ambenonium dichloride, please let us know.
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Keywords: Ambenonium dichloride, Ambenonium dichloride supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Non-selective, Muscarinics, Cholinesterases, 0388, Tocris Bioscience
2 Citations for Ambenonium dichloride
Citations are publications that use Tocris products. Selected citations for Ambenonium dichloride include:
Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263
Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. Int J Mol Sci 112 8124 PMID: 26080439
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