Alytesin

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Cat.No. 1893 - Alytesin | Glp-Gly-Arg-Leu-Gly-Thr-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 | CAS No. 31078-12-3
Description: Amphibian bombesin-like peptide
Datasheet
Citations

Biological Activity

Amphibian bombesin-like peptide. Stimulates gastric acid secretion, intestinal contraction, rat uterine contraction and hypertension in vivo in the dog. Also modulates thermoregulation following central administration in vivo.

Technical Data

M. Wt 1535.78
Formula C68H106N22O17S
Sequence XGRLGTQWAVGHLM

(Modifications: X = Glp, Met-14 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 31078-12-3
PubChem ID 25078137
InChI Key ISGGITPLKHZHOL-TXYKKBLVSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1535.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.65 mL 3.26 mL 6.51 mL
5 mM 0.13 mL 0.65 mL 1.3 mL
10 mM 0.07 mL 0.33 mL 0.65 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Anastasi (1971) Alytesin and bombesin, two peptide analogs from amphibian skin. Naunyn Schmiedebergs Arch.Pharmacol. 269 135 PMID: 4254272

Broccardo et al (1975) Relative potency of bombesin-like peptides. Br.J.Pharmacol. 55 221 PMID: 1201380

Rivier and Brown (1978) Bombesin, bombesin analogues, and related peptides: effects on thermoregulation. Biochemistry 17 1766 PMID: 656396


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Keywords: Amphibian bombesin-like peptide GRP-Preferring Receptors BB1 BB2 BB3 Gastrin-Releasing Peptide-Preferring NMB-Preferring Neuromedin B-Preferring Bombesin Bombesin Receptor Peptide

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