β-adrenoceptor (β2 > β1 > β3) and 5-HT1A receptor antagonist.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 285.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.5 mL||17.49 mL||34.99 mL|
|5 mM||0.7 mL||3.5 mL||7 mL|
|10 mM||0.35 mL||1.75 mL||3.5 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References are publications that support the biological activity of the product.
Blue et al (1990) Antagonist characterization of atypical beta adrenoceptors in guinea pig ileum: blockade by alprenolol and dihydroalprenolol. J.Pharmacol.Exp.Ther. 252 1034 PMID: 1969469
Bjorvatin et al (1992) The 5-HT1A antagonist (-)-alprenolol fails to modify sleep or zimeldine-induced sleep-waking effects in rats. Pharmacol.Biochem.Behav. 42 49 PMID: 1388278
Baker (2005) The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br.J.Pharmacol. 144 317 PMID: 15655528
If you know of a relevant reference for Alprenolol hydrochloride, please let us know.
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Citations for Alprenolol hydrochloride
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Beta-2 receptor blocker used in brain slices. No effect was found, although not sure if it was due to lack of blockade or lack of involvement of B2R in the observed process
Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.