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Biological Activity for Alprenolol hydrochloride
Alprenolol hydrochloride is a β-adrenoceptor (β2 > β1 > β3) and 5-HT1A receptor antagonist.
Technical Data for Alprenolol hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Alprenolol hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Alprenolol hydrochloride
The following data is based on the product molecular weight 285.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.5 mL||17.49 mL||34.99 mL|
|5 mM||0.7 mL||3.5 mL||7 mL|
|10 mM||0.35 mL||1.75 mL||3.5 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
Product Datasheets for Alprenolol hydrochloride
References for Alprenolol hydrochloride
References are publications that support the biological activity of the product.
Blue et al (1990) Antagonist characterization of atypical beta adrenoceptors in guinea pig ileum: blockade by alprenolol and dihydroalprenolol. J.Pharmacol.Exp.Ther. 252 1034 PMID: 1969469
Bjorvatin et al (1992) The 5-HT1A antagonist (-)-alprenolol fails to modify sleep or zimeldine-induced sleep-waking effects in rats. Pharmacol.Biochem.Behav. 42 49 PMID: 1388278
Baker (2005) The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br.J.Pharmacol. 144 317 PMID: 15655528
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Citations for Alprenolol hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Alprenolol hydrochloride. Do you know of a great paper that uses Alprenolol hydrochloride from Tocris? Please let us know.
Reviews for Alprenolol hydrochloride
Average Rating: 3 (Based on 1 Review.)
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Beta-2 receptor blocker used in brain slices. No effect was found, although not sure if it was due to lack of blockade or lack of involvement of B2R in the observed process
Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.