[Ala17]-MCH

Pricing Availability Delivery Time Qty
Cat.No. 3434 - [Ala17]-MCH | Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Ala-Gln-Val | CAS No. 359784-84-2
Description: Potent MCH receptor agonist
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively).

Technical Data

M. Wt 2271.71
Formula C97H155N29O26S4
Sequence DFDMLRCMLGRVYRPCAQV

(Modifications: Disulfide bridge between 7 - 16)

Storage Store at -20°C
CAS Number 359784-84-2
PubChem ID 90488845
InChI Key IVEALEKXBDDRGB-UKPWUPKZSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2271.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.44 mL 2.2 mL 4.4 mL
5 mM 0.09 mL 0.44 mL 0.88 mL
10 mM 0.04 mL 0.22 mL 0.44 mL
50 mM 0.01 mL 0.04 mL 0.09 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bednarek et al (2001) Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. Biochemistry 40 9379 PMID: 11478907

Gao et al (2004) Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal.Biochem. 328 187 PMID: 15113696


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View Related Products by Product Action

View all Melanin-concentrating Hormone Receptor Agonists

Keywords: [Ala17]-MCH, supplier, Potent, MCH, receptors, agonists, Melanin-concentrating, Hormone, MCH1, MCH2, MCH2R, MCHR2, MCH1R, MCHR1, Melanin-concentrating, Hormone, Receptors, Melanin-concentrating, Hormone, Receptors, Tocris Bioscience

1 Citation for [Ala17]-MCH

Citations are publications that use Tocris products. Selected citations for [Ala17]-MCH include:

Camp et al (2016) Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics. Pharmacol Res 105 13 PMID: 26773201


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