Potent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively).
(Modifications: Disulfide bridge between 7 - 16)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 2271.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.44 mL||2.2 mL||4.4 mL|
|5 mM||0.09 mL||0.44 mL||0.88 mL|
|10 mM||0.04 mL||0.22 mL||0.44 mL|
|50 mM||0.01 mL||0.04 mL||0.09 mL|
References are publications that support the products' biological activity.
Bednarek et al (2001) Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. Biochemistry 40 9379 PMID: 11478907
Gao et al (2004) Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal.Biochem. 328 187 PMID: 15113696
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Keywords: [Ala17]-MCH, supplier, Potent, MCH, receptors, agonists, Melanin-concentrating, Hormone, MCH1, MCH2, MCH2R, MCHR2, MCH1R, MCHR1, Melanin-concentrating, Hormone, Receptors, Melanin-concentrating, Hormone, Receptors, Tocris Bioscience
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