[Ala1,3,11,15]-Endothelin

Pricing Availability Delivery Time Qty
Cat.No. 1197 - [Ala1,3,11,15]-Endothelin | Ala-Ser-Ala-Ser-Ser-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp | CAS No. 121204-87-3
Description: Selective ETB agonist
Datasheet
Citations
Literature

Biological Activity

Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).

Technical Data

M. Wt 2368
Formula C109H163N25O32S
Sequence ASASSLMDKEAVYFAHLDIIW
Storage Desiccate at -20°C
CAS Number 121204-87-3
PubChem ID 16143287
InChI Key NRTWVLDGYXCWHD-IGKRDWOESA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2368. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.42 mL 2.11 mL 4.22 mL
5 mM 0.08 mL 0.42 mL 0.84 mL
10 mM 0.04 mL 0.21 mL 0.42 mL
50 mM 0.01 mL 0.04 mL 0.08 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Nakamichi et al (1992) Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET1. Biochem.Biophys.Res.Commun. 182 144 PMID: 1310013

Panek et al (1992) Endothelin and structurally related analogs distinguish between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 183 566 PMID: 1312833


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Keywords: [Ala1,3,11,15]-Endothelin, supplier, Selective, ETB, agonists, Receptors, Endothelin, Endothelin, ETB, Receptors, Endothelin, ETB, Receptors, Tocris Bioscience

Citations for [Ala1,3,11,15]-Endothelin

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