AKOS 022

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Description: Voltage-dependent anion channel (VDAC) inhibitor
Chemical Name: 1-(4-Chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]-2,5-pyrrolidinedione
Purity: ≥98% (HPLC)

Biological Activity for AKOS 022

AKOS 022 is a voltage-dependent anion channel (VDAC; Kd = 154 μM) inhibitor, which reduces channel conductance. In HEK-293 cells, AKOS 022 inhibits selenium-induced VDAC oligomerization, cytochrome C release from mitochondria and apoptosis (IC50 values range from 3.3 to 3.6 μM). AKOS 022 also prevents glucotoxicity-mediated overexpression of VDAC1 in INS-1 cells.

Compound Libraries for AKOS 022

AKOS 022 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AKOS 022

M. Wt 467.87
Formula C22H21ClF3N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 878983-38-1
PubChem ID 5304523
Smiles FC(F)(OC1=CC=C(C=C1)NC2CCN(C3CC(N(C4=CC=C(C=C4)Cl)C3=O)=O)CC2)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AKOS 022

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.79 100

Preparing Stock Solutions for AKOS 022

The following data is based on the product molecular weight 467.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.69 mL 21.37 mL
5 mM 0.43 mL 2.14 mL 4.27 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References for AKOS 022

References are publications that support the biological activity of the product.

Ben-Hail et al (2016) Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondrial dysfunction. J.Biol.Chem. 291 24986 PMID: 27738100

Zhang et al (2019) Preserving insulin secretion in diabetes by inhibiting VDAC1 overexpression and surface translocation in β cells. Cell Metab. 29 64 PMID: 30293774

If you know of a relevant reference for AKOS 022, please let us know.

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Citations for AKOS 022

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