AH 6809

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Cat.No. 0671 - AH 6809 | C17H14O5 | CAS No. 33458-93-4
Description: EP1 and EP2 receptor antagonist
Chemical Name: 6-Isopropoxy-9-xanthone-2-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Literature

Biological Activity

Antagonist at prostaglandin EP1 (pA2 = 6.8) and EP2 (Ki = 350 nM) receptors. Also weakly inhibits DP receptors (pA2 = 4.45).

Compound Libraries

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Technical Data

M. Wt 298.3
Formula C17H14O5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 33458-93-4
PubChem ID 119461
InChI Key AQFFXPQJLZFABJ-UHFFFAOYSA-N
Smiles CC(C)OC1=CC=C2C(OC3=C(C=C(C=C3)C(O)=O)C2=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 29.83 100
DMSO 29.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 298.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.76 mL 33.52 mL
5 mM 0.67 mL 3.35 mL 6.7 mL
10 mM 0.34 mL 1.68 mL 3.35 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Keery and Lumley (1988) AH 6809, a prostaglandin DP-receptor blocking drug on human platelets. Br.J.Pharmacol. 94 745 PMID: 2460179

Kiriyama et al (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 122 217 PMID: 9313928

van der Merwe et al (2009) Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2. J.Pharmacol.Exp.Ther. 329 747 PMID: 19190238

Coleman et al (1985) AH6809, a prostanoid EP1-receptor blocking drug. Br.J.Pharmacol. 85 273P PMID:


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Keywords: EP1 EP2 receptor antagonists DP Receptors prostanoid receptors prostaglandins prostacyclins eicosanoids AH6809 Prostanoid Receptors

6 Citations for AH 6809

Citations are publications that use Tocris products. Selected citations for AH 6809 include:

Liu et al (2016) Oxidized phospholipid OxPAPC activates TRPA1 and contributes to chronic inflammatory pain in mice PLoS One 11 e0165200 PMID: 27812120

Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Dent Res J (Isfahan) 19 210 PMID: 25266063

Chia et al (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol 11 10 PMID: 21955547

Passafaro et al (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Br J Pharmacol 8 138 PMID: 22013477

Schaafsma et al (2007) Insulin induces airway smooth muscle contraction. J Pharmacol Exp Ther 150 136 PMID: 17160007

Walsh and Kinsella (2000) Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors. Br J Pharmacol 131 601 PMID: 11015313


Do you know of a great paper that uses AH 6809 from Tocris? If so please let us know.

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Pathways for AH 6809

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