You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for AH 6809
AH 6809 is an antagonist at prostaglandin EP1 (pA2 = 6.8) and EP2 (Ki = 350 nM) receptors. Also weakly inhibits DP receptors (pA2 = 4.45).
Compound Libraries for AH 6809
Technical Data for AH 6809
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AH 6809
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AH 6809
The following data is based on the product molecular weight 298.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.35 mL||16.76 mL||33.52 mL|
|5 mM||0.67 mL||3.35 mL||6.7 mL|
|10 mM||0.34 mL||1.68 mL||3.35 mL|
|50 mM||0.07 mL||0.34 mL||0.67 mL|
References for AH 6809
References are publications that support the biological activity of the product.
Keery and Lumley (1988) AH 6809, a prostaglandin DP-receptor blocking drug on human platelets. Br.J.Pharmacol. 94 745 PMID: 2460179
Kiriyama et al (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 122 217 PMID: 9313928
van der Merwe et al (2009) Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2. J.Pharmacol.Exp.Ther. 329 747 PMID: 19190238
Coleman et al (1985) AH6809, a prostanoid EP1-receptor blocking drug. Br.J.Pharmacol. 85 273P
If you know of a relevant reference for AH 6809, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: AH 6809, AH 6809 supplier, EP1, EP2, receptor, antagonists, DP, Receptors, prostanoid, receptors, prostaglandins, prostacyclins, eicosanoids, AH6809, Prostanoid, 0671, Tocris Bioscience
6 Citations for AH 6809
Citations are publications that use Tocris products. Selected citations for AH 6809 include:
Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Dent Res J (Isfahan) 19 210 PMID: 25266063
Walsh and Kinsella (2000) Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors. Br J Pharmacol 131 601 PMID: 11015313
Chia et al (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol 11 10 PMID: 21955547
Passafaro et al (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Br J Pharmacol 8 138 PMID: 22013477
Schaafsma et al (2007) Ins induces airway smooth muscle contraction. J Pharmacol Exp Ther 150 136 PMID: 17160007
Liu et al (2016) Oxidized phospholipid OxPAPC activates TRPA1 and contributes to chronic inflammatory pain in mice PLoS One 11 e0165200 PMID: 27812120
Do you know of a great paper that uses AH 6809 from Tocris? Please let us know.
Reviews for AH 6809
There are currently no reviews for this product. Be the first to review AH 6809 and earn rewards!
Have you used AH 6809?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.