AH 11110 hydrochloride
A subtype-selective ligand for the α1B-adrenoceptor. The pKi values for binding to rat fibroblast cell membranes expressing α1B (hamster), α1A (bovine) and α1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α1 subtypes and α2 receptors in smooth muscle preparations.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 25 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 374.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.67 mL||13.34 mL||26.67 mL|
|5 mM||0.53 mL||2.67 mL||5.33 mL|
|10 mM||0.27 mL||1.33 mL||2.67 mL|
|50 mM||0.05 mL||0.27 mL||0.53 mL|
References are publications that support the products' biological activity.
Eltze et al (2001) Failure of AH11110A to functionally discriminate between α1-adrenoceptor subtypes A, B and D or between α1- and α2-adrenoceptors. Eur.J.Pharmacol. 415 265 PMID: 11275009
Saussy et al (1996) Structure-activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 278 136 PMID: 8764344
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