AH 11110 hydrochloride

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Cat.No. 0998 - AH 11110 hydrochloride | C21H26N2O2.HCl | CAS No. 179388-65-9
Description: Subtype-selective α1B ligand
Chemical Name: 4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

A subtype-selective ligand for the α1B-adrenoceptor. The pKi values for binding to rat fibroblast cell membranes expressing α1B (hamster), α1A (bovine) and α1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α1 subtypes and α2 receptors in smooth muscle preparations.

Technical Data

M. Wt 374.91
Formula C21H26N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 179388-65-9
PubChem ID 9907616
InChI Key WWHGFIXWBLHHQB-UHFFFAOYSA-N
Smiles Cl.OC(COC1=C(C=CC=C1)C1=CC=CC=C1)CC(=N)N1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 25 mM in water

References

References are publications that support the biological activity of the product.

Eltze et al (2001) Failure of AH11110A to functionally discriminate between α1-adrenoceptor subtypes A, B and D or between α1- and α2-adrenoceptors. Eur.J.Pharmacol. 415 265 PMID: 11275009

Saussy et al (1996) Structure-activity relationships of a series of busp. analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 278 136 PMID: 8764344

King et al (1994) AH 11110A is selective for the α1B-subtype of α1-adrenoceptors. Soc.Neurosci.Abstr. 20 526


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Citations for AH 11110 hydrochloride

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