AH 11110 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 0998 - AH 11110 hydrochloride | C21H26N2O2.HCl | CAS No. 179388-65-9
Description: Subtype-selective α1B ligand
Chemical Name: 4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

A subtype-selective ligand for the α1B-adrenoceptor. The pKi values for binding to rat fibroblast cell membranes expressing α1B (hamster), α1A (bovine) and α1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α1 subtypes and α2 receptors in smooth muscle preparations.

Technical Data

M. Wt 374.91
Formula C21H26N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 179388-65-9
PubChem ID 9907616
InChI Key WWHGFIXWBLHHQB-UHFFFAOYSA-N
Smiles Cl.OC(COC1=C(C=CC=C1)C1=CC=CC=C1)CC(=N)N1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 25 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 374.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.34 mL 26.67 mL
5 mM 0.53 mL 2.67 mL 5.33 mL
10 mM 0.27 mL 1.33 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Eltze et al (2001) Failure of AH11110A to functionally discriminate between α1-adrenoceptor subtypes A, B and D or between α1- and α2-adrenoceptors. Eur.J.Pharmacol. 415 265 PMID: 11275009

Saussy et al (1996) Structure-activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 278 136 PMID: 8764344

King et al (1994) AH 11110A is selective for the α1B-subtype of α1-adrenoceptors. Soc.Neurosci.Abstr. 20 526 PMID:


If you know of a relevant reference for AH 11110 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Adrenergic α1 Receptor Ligands

Keywords: AH 11110 hydrochloride, supplier, Subtype-selective, α1B-adrenoceptor, alpha1B-adrenoceptor, α1b-adrenergic, alpha1b-adrenergic, a1b-adrenoceptor, a1b-adrenergic, ligands, Receptors, AH11110, hydrochloride, Adrenergic, Alpha-1, Receptors, Adrenergic, Alpha-1, Receptors, Tocris Bioscience

Citations for AH 11110 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for AH 11110 hydrochloride. Do you know of a great paper that uses AH 11110 hydrochloride from Tocris? If so please let us know.

AH 11110 hydrochloride Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used AH 11110 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.