AH 11110 hydrochloride

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Cat.No. 0998 - AH 11110 hydrochloride | C21H26N2O2.HCl | CAS No. 179388-65-9
Description: Subtype-selective α1B ligand
Chemical Name: 4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

A subtype-selective ligand for the α1B-adrenoceptor. The pKi values for binding to rat fibroblast cell membranes expressing α1B (hamster), α1A (bovine) and α1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α1 subtypes and α2 receptors in smooth muscle preparations.

Technical Data

M. Wt 374.91
Formula C21H26N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 179388-65-9
PubChem ID 9907616
Smiles Cl.OC(COC1=C(C=CC=C1)C1=CC=CC=C1)CC(=N)N1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 25 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 374.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.34 mL 26.67 mL
5 mM 0.53 mL 2.67 mL 5.33 mL
10 mM 0.27 mL 1.33 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Eltze et al (2001) Failure of AH11110A to functionally discriminate between α1-adrenoceptor subtypes A, B and D or between α1- and α2-adrenoceptors. Eur.J.Pharmacol. 415 265 PMID: 11275009

Saussy et al (1996) Structure-activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 278 136 PMID: 8764344

King et al (1994) AH 11110A is selective for the α1B-subtype of α1-adrenoceptors. Soc.Neurosci.Abstr. 20 526 PMID:

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