Selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 434.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.3 mL||11.51 mL||23.03 mL|
|5 mM||0.46 mL||2.3 mL||4.61 mL|
|10 mM||0.23 mL||1.15 mL||2.3 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Outeiro et al (2007) Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease. Science 317 516 PMID: 17588900
If you know of a relevant reference for AGK 2, please let us know.
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Keywords: Selective SIRT2 inhibitors inhibits Sirtuin Sir2-like Family Deacetylases AGK2 Sir2-like Family Deacetylases
3 Citations for AGK 2
Citations are publications that use Tocris products. Selected citations for AGK 2 include:
Newton et al (2014) Is SIRT2 required for necroptosis? Nature 506 E4 PMID: 24572428
Snider et al (2013) Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. Adipocyte 200 241 PMID: 23358244
Xu et al (2013) Temporal analysis of protein lysine acetylation during adipocyte differentiation. J Pharmacol Exp Ther 2 33 PMID: 23700550
Do you know of a great paper that uses AGK 2 from Tocris? If so please let us know.