AGK 2

Pricing Availability   Qty
Cat.No. 3233 - AGK 2 | C23H13Cl2N3O2 | CAS No. 304896-28-4
Description: Selective SIRT2 inhibitor
Chemical Name: 2-Cyano-3-[[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (3)

Biological Activity

Selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.

Technical Data

M. Wt 434.27
Formula C23H13Cl2N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 304896-28-4
PubChem ID 2130404
InChI Key SVENPFFEMUOOGK-SDNWHVSQSA-N
Smiles O=C(/C(C#N)=C/C3=CC=C(C4=C(Cl)C=CC(Cl)=C4)O3)NC2=CC=CC1=NC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.34 10

Preparing Stock Solutions

The following data is based on the product molecular weight 434.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.03 mL 115.14 mL 230.27 mL
0.5 mM 4.61 mL 23.03 mL 46.05 mL
1 mM 2.3 mL 11.51 mL 23.03 mL
5 mM 0.46 mL 2.3 mL 4.61 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Outeiro et al (2007) Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease. Science 317 516 PMID: 17588900


If you know of a relevant reference for AGK 2, please let us know.

View Related Products by Product Action

View all Class III HDAC (Sirtuin) Inhibitors

Keywords: AGK 2, AGK 2 supplier, Selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, AGK2, Class, III, HDACs, (Sirtuins), 3233, Tocris Bioscience

3 Citations for AGK 2

Citations are publications that use Tocris products. Selected citations for AGK 2 include:

Snider et al (2013) Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. Adipocyte 200 241 PMID: 23358244

Xu et al (2013) Temporal analysis of protein lysine acetylation during adipocyte differentiation. J Pharmacol Exp Ther 2 33 PMID: 23700550

Newton et al (2014) Is SIRT2 required for necroptosis? Nature 506 E4 PMID: 24572428


Do you know of a great paper that uses AGK 2 from Tocris? Please let us know.

Reviews for AGK 2

There are currently no reviews for this product. Be the first to review AGK 2 and earn rewards!

Have you used AGK 2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Rheumatoid Arthritis

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.