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Selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 434.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||23.03 mL||115.14 mL||230.27 mL|
|0.5 mM||4.61 mL||23.03 mL||46.05 mL|
|1 mM||2.3 mL||11.51 mL||23.03 mL|
|5 mM||0.46 mL||2.3 mL||4.61 mL|
References are publications that support the biological activity of the product.
Outeiro et al (2007) Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease. Science 317 516 PMID: 17588900
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Keywords: AGK 2, AGK 2 supplier, Selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, AGK2, Class, III, HDACs, (Sirtuins), 3233, Tocris Bioscience
3 Citations for AGK 2
Citations are publications that use Tocris products. Selected citations for AGK 2 include:
Snider et al (2013) Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. Adipocyte 200 241 PMID: 23358244
Xu et al (2013) Temporal analysis of protein lysine acetylation during adipocyte differentiation. J Pharmacol Exp Ther 2 33 PMID: 23700550
Newton et al (2014) Is SIRT2 required for necroptosis? Nature 506 E4 PMID: 24572428
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Literature in this Area
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