AGK 2

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Cat.No. 3233 - AGK 2 | C23H13Cl2N3O2 | CAS No. 304896-28-4
Description: Selective SIRT2 inhibitor
Chemical Name: 2-Cyano-3-[[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.

Technical Data

M. Wt 434.27
Formula C23H13Cl2N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 304896-28-4
PubChem ID 2130404
InChI Key SVENPFFEMUOOGK-SDNWHVSQSA-N
Smiles O=C(/C(C#N)=C/C3=CC=C(C4=C(Cl)C=CC(Cl)=C4)O3)NC2=CC=CC1=NC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.34 10

Preparing Stock Solutions

The following data is based on the product molecular weight 434.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.51 mL 23.03 mL
5 mM 0.46 mL 2.3 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Outeiro et al (2007) Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease. Science 317 516 PMID: 17588900


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Keywords: AGK 2, supplier, Selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, AGK2, Sir2-like, Family, Deacetylases, Sir2-like, Family, Deacetylases, Tocris Bioscience

3 Citations for AGK 2

Citations are publications that use Tocris products. Selected citations for AGK 2 include:

Newton et al (2014) Is SIRT2 required for necroptosis? Nature 506 E4 PMID: 24572428

Snider et al (2013) Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. Adipocyte 200 241 PMID: 23358244

Xu et al (2013) Temporal analysis of protein lysine acetylation during adipocyte differentiation. J Pharmacol Exp Ther 2 33 PMID: 23700550


Do you know of a great paper that uses AGK 2 from Tocris? If so please let us know.

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Literature in this Area

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Neurodegeneration

Neurodegeneration Product Guide

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Pathways for AGK 2

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