AG 045572

Pricing Availability Delivery Time Qty
Cat.No. 2730 - AG 045572 | C30H37NO5 | CAS No. 263847-55-8
Description: Selective GnRH receptor antagonist
Chemical Name: 5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl-methyl]-N-(2,4,6-trimethoxyphenyl)-2-furancarboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Suppresses testosterone and luteinising hormone (LH) levels in vivo.

Technical Data

M. Wt 491.62
Formula C30H37NO5
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 263847-55-8
PubChem ID 9957278
InChI Key IPEMCIBPDYCJLO-UHFFFAOYSA-N
Smiles CC(CCC(C)2C)(C)C1=C2C=C(C)C(CC3=CC=C(C(NC4=C(OC)C=C(OC)C=C4OC)=O)O3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.16 100
ethanol 24.58 50

Preparing Stock Solutions

The following data is based on the product molecular weight 491.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.17 mL 20.34 mL
5 mM 0.41 mL 2.03 mL 4.07 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Iatsimirskaia et al (2002) Effect of testosterone suppression on the pharmacokinetics of a potent GnRH receptor antagonist. Pharm.Res. 19 202 PMID: 11883648

Anderes et al (2003) Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats. J.Pharmacol.Exp.Ther. 305 688 PMID: 12606616


If you know of a relevant reference for AG 045572, please let us know.

View Related Products by Product Action

View all Gonadotropin-Releasing Hormone Receptor Antagonists

Keywords: Selective GnRH receptor antagonists Receptors Gonadotrophin-Releasing Hormone AG045572 gonadotropin Gonadotrophin-Releasing Hormone Receptors

Citations for AG 045572

Citations are publications that use Tocris products.

Currently there are no citations for AG 045572. Do you know of a great paper that uses AG 045572 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing

Pathways for AG 045572

Protocols

TODO: Add Protocols