Selective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Suppresses testosterone and luteinising hormone (LH) levels in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 491.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.03 mL||10.17 mL||20.34 mL|
|5 mM||0.41 mL||2.03 mL||4.07 mL|
|10 mM||0.2 mL||1.02 mL||2.03 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
References are publications that support the products' biological activity.
Iatsimirskaia et al (2002) Effect of testosterone suppression on the pharmacokinetics of a potent GnRH receptor antagonist. Pharm.Res. 19 202 PMID: 11883648
Anderes et al (2003) Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats. J.Pharmacol.Exp.Ther. 305 688 PMID: 12606616
If you know of a relevant reference for AG 045572, please let us know.
View Related Products by Product Action
Keywords: AG 045572, supplier, Selective, GnRH, receptor, antagonists, Receptors, Gonadotrophin-Releasing, Hormone, AG045572, gonadotropin, Gonadotrophin-Releasing, Hormone, Receptors, Gonadotrophin-Releasing, Hormone, Receptors, Tocris Bioscience
Citations for AG 045572
Citations are publications that use Tocris products.
Currently there are no citations for AG 045572. Do you know of a great paper that uses AG 045572 from Tocris? If so please let us know.
Reviews for AG 045572
There are currently no reviews for this product. Be the first to review AG 045572 and earn rewards!
Have you used AG 045572?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review