ACT 462206

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Cat.No. 5319 - ACT 462206 | C20H24N2O4S | CAS No. 1361321-96-1
Description: Potent, dual orexin receptor antagonist
Chemical Name: (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations

Biological Activity

Potent, dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.

Compound Libraries

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Technical Data

M. Wt 388.48
Formula C20H24N2O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1361321-96-1
PubChem ID 40924317
InChI Key NHPQGZOBHSVTAQ-IBGZPJMESA-N
Smiles CC1=CC(NC([C@@H]2CCCN2S(C3=CC=C(OC)C=C3)(=O)=O)=O)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.85 100
ethanol 38.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 388.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.87 mL 25.74 mL
5 mM 0.51 mL 2.57 mL 5.15 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Boss et al (2014) Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 9 2486 PMID: 25147058


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Keywords: ACT462206 Potent dual orexin receptors antagonists OX1 OX2 DORA anxiolytic Non-selective Orexin

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