ACT 462206

Pricing Availability   Qty
Description: Potent, dual orexin receptor antagonist
Chemical Name: (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for ACT 462206

ACT 462206 is a potent, dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.

Compound Libraries for ACT 462206

ACT 462206 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ACT 462206

M. Wt 388.48
Formula C20H24N2O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1361321-96-1
PubChem ID 40924317
Smiles CC1=CC(NC([C@@H]2CCCN2S(C3=CC=C(OC)C=C3)(=O)=O)=O)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ACT 462206

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.85 100
ethanol 38.85 100

Preparing Stock Solutions for ACT 462206

The following data is based on the product molecular weight 388.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.87 mL 25.74 mL
5 mM 0.51 mL 2.57 mL 5.15 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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References for ACT 462206

References are publications that support the biological activity of the product.

Boss et al (2014) Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 9 2486 PMID: 25147058

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Keywords: ACT 462206, ACT 462206 supplier, ACT462206, Potent, dual, orexin, receptors, antagonists, OX1, OX2, DORA, anxiolytic, Non-selective, Orexin, 5319, Tocris Bioscience

1 Citation for ACT 462206

Citations are publications that use Tocris products. Selected citations for ACT 462206 include:

Abdel A et al (2021) Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension. Sci Rep 11 21050 PMID: 34702886

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.