Pricing Availability   Qty
Description: Glucosidase α inhibitor (intestinal)
Alternative Names: Bay-g 5421
Chemical Name: O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1-4)-O-α-D-glucopyranosyl-(1-4)-D-Glucose

Biological Activity for Acarbose

Acarbose is an inhibitor of intestinal α-glucosidase (IC50 = 11 nM). Antidiabetic; inhibits the hydrolysis of complex carbohydrates.

Compound Libraries for Acarbose

Acarbose is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Acarbose

M. Wt 645.25
Formula C25H43NO18
Storage Desiccate at RT
CAS Number 56180-94-0
PubChem ID 444254
Smiles C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Acarbose

Solvent Max Conc. mg/mL Max Conc. mM
water 64.52 100
DMSO 64.52 100

Preparing Stock Solutions for Acarbose

The following data is based on the product molecular weight 645.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.55 mL 7.75 mL 15.5 mL
5 mM 0.31 mL 1.55 mL 3.1 mL
10 mM 0.15 mL 0.77 mL 1.55 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets for Acarbose

Certificate of Analysis / Product Datasheet
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References for Acarbose

References are publications that support the biological activity of the product.

Krause et al (1982) Inhibition of disaccharide digestion in rat intestine by the alpha-glucosidase inhibitor aca. (BAY g 5421). Digestion 23 232 PMID: 6754513

Balfour and McTavish (1993) Acarbose: an update of its pharmacology and therapeutic use in diabetes mellitus. Drugs 46 1025 PMID: 7510610

Oki et al (2000) Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol.Pharm.Bull. 23 1084 PMID: 10993209

If you know of a relevant reference for Acarbose, please let us know.

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Keywords: Acarbose, Acarbose supplier, Glucosidase, alpha, inhibitors, inhibits, intestinal, Glycosylases, Carbohydrate, Metabolism, Bay-g5421, Bay-g, 5421, 2673, Tocris Bioscience

Citations for Acarbose

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