Acarbose

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Cat.No. 2673 - Acarbose | C25H43NO18 | CAS No. 56180-94-0
Description: Glucosidase α inhibitor (intestinal)
Alternative Names: Bay-g 5421
Chemical Name: O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1-4)-O-α-D-glucopyranosyl-(1-4)-D-Glucose
Datasheet
Citations
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Literature

Biological Activity

Inhibitor of intestinal α-glucosidase (IC50 = 11 nM). Antidiabetic; inhibits the hydrolysis of complex carbohydrates.

Compound Libraries

Acarbose is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 645.25
Formula C25H43NO18
Storage Desiccate at RT
CAS Number 56180-94-0
PubChem ID 444254
InChI Key XUFXOAAUWZOOIT-SXARVLRPSA-N
Smiles C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 64.52 100
DMSO 64.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 645.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.55 mL 7.75 mL 15.5 mL
5 mM 0.31 mL 1.55 mL 3.1 mL
10 mM 0.15 mL 0.77 mL 1.55 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Krause et al (1982) Inhibition of disaccharide digestion in rat intestine by the alpha-glucosidase inhibitor acarbose (BAY g 5421). Digestion 23 232 PMID: 6754513

Balfour and McTavish (1993) Acarbose: an update of its pharmacology and therapeutic use in diabetes mellitus. Drugs 46 1025 PMID: 7510610

Oki et al (2000) Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol.Pharm.Bull. 23 1084 PMID: 10993209


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Keywords: Acarbose, Acarbose supplier, Glucosidase, alpha, inhibitors, inhibits, intestinal, Glycosylases, Carbohydrate, Metabolism, Bay-g5421, Bay-g, 5421, 2673, Tocris Bioscience

Citations for Acarbose

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Literature in this Area

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