Ac2-12

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Cat.No. 1846 - Ac2-12 | Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp | CAS No. 256447-08-2
Description: Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
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Citations
Literature

Biological Activity

Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.

Licensing Information

Sold under license from The William Harvey Research Institute

Technical Data

M. Wt 1351.58
Formula C63H94N14O17S
Sequence AMVSEFLKQAW

(Modifications: Ala-1 = N-terminal Ac)

Storage Desiccate at -20°C
CAS Number 256447-08-2
PubChem ID 90488718
InChI Key SUDAISORCUBKHK-RCVXMRHOSA-N
Smiles CSCC[C@H](NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 20% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1351.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.74 mL 3.7 mL 7.4 mL
5 mM 0.15 mL 0.74 mL 1.48 mL
10 mM 0.07 mL 0.37 mL 0.74 mL
50 mM 0.01 mL 0.07 mL 0.15 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 Proc.Natl.Acad.Sci.U.S.A. 95 14535 PMID: 9826735

Perretti et al (2001) Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am.J.Pathol. 158 1969 PMID: 11395373


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Keywords: Ac2-12, supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Cell, Adhesion, Molecules, Tocris Bioscience

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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