Ac2-12

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Cat.No. 1846 - Ac2-12 | Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp | CAS No. 256447-08-2
Description: Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
Datasheet
Citations
Reviews
Literature

Biological Activity

Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.

Licensing Information

Sold under license from The William Harvey Research Institute

Technical Data

M. Wt 1351.58
Formula C63H94N14O17S
Sequence AMVSEFLKQAW

(Modifications: Ala-1 = N-terminal Ac)

Storage Desiccate at -20°C
CAS Number 256447-08-2
PubChem ID 90488718
InChI Key SUDAISORCUBKHK-RCVXMRHOSA-N
Smiles CSCC[C@H](NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in 20% acetonitrile / water

References

References are publications that support the biological activity of the product.

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 Proc.Natl.Acad.Sci.U.S.A. 95 14535 PMID: 9826735

Perretti et al (2001) Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am.J.Pathol. 158 1969 PMID: 11395373


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Keywords: Ac2-12, Ac2-12 supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Cell, 1846, Tocris Bioscience

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