Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.
Sold under license from The William Harvey Research Institute
(Modifications: Ala-1 = N-terminal Ac)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in 20% acetonitrile / water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1351.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.74 mL||3.7 mL||7.4 mL|
|5 mM||0.15 mL||0.74 mL||1.48 mL|
|10 mM||0.07 mL||0.37 mL||0.74 mL|
|50 mM||0.01 mL||0.07 mL||0.15 mL|
References are publications that support the products' biological activity.
Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 Proc.Natl.Acad.Sci.U.S.A. 95 14535 PMID: 9826735
Perretti et al (2001) Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am.J.Pathol. 158 1969 PMID: 11395373
If you know of a relevant reference for Ac2-12, please let us know.
Keywords: Ac2-12, supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Cell, Adhesion, Molecules, Cell, Adhesion, Molecules, Tocris Bioscience
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