AC 4

Discontinued Product

AC 4 (Cat. No. 5464) has been withdrawn from sale for commercial reasons.
Description: Photoswitchable TRPV1 channel blocker
Chemical Name: 1,3,4,5-Tetrahydro-7,8-dihydro-N-[2-[4-[2-[4-(trifluoromethyl)phenyl]diazenyl]phenyl]ethyl]-2H-2-benzazepine-2-carbothioamide
Purity: ≥98% (HPLC)

Biological Activity for AC 4

AC 4 is a photoswitchable TRPV1 channel blocker (IC50 = 3.1 μM). Acts as an antagonist in trans conformation during voltage gated activation. Also acts as an antagonist in the cis formation during capsaicin-induced TRPV1 currents. Switches conformation from cis to trans at 440 nm and trans to cis at 360 nm. Allows photoswitchable antagonist and an agonist to be applied at the same time.

Technical Data for AC 4

M. Wt 514.56
Formula C26H25F3N4O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1459809-09-6
PubChem ID 121513863
Smiles S=C(NCCC3=CC=C(/N=N/C4=CC=C(C(F)(F)F)C=C4)C=C3)N(CCC2)CC1=C2C=C(O)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AC 4

References are publications that support the biological activity of the product.

Stein et al (2013) Optical control of TRPV1 channels. Angew.Chem.Int.Ed.Engl. 52 9845 PMID: 23873837

Keywords: AC 4, AC 4 supplier, Photoswitchable, TRPV1, channel, blockers, transient, receptor, potential, vanilloids, ligands, Ligands, TRPV, 5464, Tocris Bioscience

Citations for AC 4

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Currently there are no citations for AC 4.

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