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Biological Activity for AC 45594
AC 45594 is a selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM). Displays no activity at estrogen, LRH-1, ROR, ERR or Nurr receptors. Inhibits SFRE-mediated transcription.
Technical Data for AC 45594
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AC 45594
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AC 45594
The following data is based on the product molecular weight 208.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.8 mL||24 mL||48.01 mL|
|5 mM||0.96 mL||4.8 mL||9.6 mL|
|10 mM||0.48 mL||2.4 mL||4.8 mL|
|50 mM||0.1 mL||0.48 mL||0.96 mL|
References for AC 45594
References are publications that support the biological activity of the product.
Del Tredici et al (2008) Identification of the first synthetic steroidogenic factor 1 inverse agonist.: pharmacological modulation of steroidogenic enymes. Mol.Pharmacol. 73 900 PMID: 18055761
If you know of a relevant reference for AC 45594, please let us know.
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Keywords: AC 45594, AC 45594 supplier, SF-1, inverse, agonists, Nuclear, Receptors, Steroidogenic, Factor-1, AC45594, Other, 3043, Tocris Bioscience
Citations for AC 45594
Citations are publications that use Tocris products.
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Literature in this Area
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