Selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM). Displays no activity at estrogen, LRH-1, ROR, ERR or Nurr receptors. Inhibits SFRE-mediated transcription.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 208.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.8 mL||24 mL||48.01 mL|
|5 mM||0.96 mL||4.8 mL||9.6 mL|
|10 mM||0.48 mL||2.4 mL||4.8 mL|
|50 mM||0.1 mL||0.48 mL||0.96 mL|
References are publications that support the products' biological activity.
Del Tredici et al (2008) Identification of the first synthetic steroidogenic factor 1 inverse agonist.: pharmacological modulation of steroidogenic enymes. Mol.Pharmacol. 73 900 PMID: 18055761
If you know of a relevant reference for AC 45594, please let us know.
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Keywords: AC 45594, supplier, SF-1, inverse, agonists, Nuclear, Receptors, Steroidogenic, Factor-1, AC45594, Other, Nuclear, Receptors, Other, Nuclear, Receptors, Tocris Bioscience
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