You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for AC 265347
AC 265347 is a CaSR biased allosteric modulator (pEC50 = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABAB or type I PTH receptors. Orally active.
Compound Libraries for AC 265347
Technical Data for AC 265347
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AC 265347
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AC 265347
The following data is based on the product molecular weight 283.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.53 mL||17.64 mL||35.29 mL|
|5 mM||0.71 mL||3.53 mL||7.06 mL|
|10 mM||0.35 mL||1.76 mL||3.53 mL|
|50 mM||0.07 mL||0.35 mL||0.71 mL|
References for AC 265347
References are publications that support the biological activity of the product.
Cook et al (2015) Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. Br.J.Pharmacol. 172 185 PMID: 25220431
Ma et al (2011) Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 337 275 PMID: 21239511
Leach et al (2016) Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell.Res. 26 574 PMID: 27002221
If you know of a relevant reference for AC 265347, please let us know.
View Related Products by Product Action
Keywords: AC 265347, AC 265347 supplier, AC265347, CaSR, biased, allosteric, modulator, calcimimetic, parathyroid, homrone, PTH, calcitonin, PERK1/2, IP1, accumulation, orally, active, Calcium-Sensing, Receptor, 6165, Tocris Bioscience
Citations for AC 265347
Citations are publications that use Tocris products.
Currently there are no citations for AC 265347. Do you know of a great paper that uses AC 265347 from Tocris? Please let us know.
Reviews for AC 265347
There are currently no reviews for this product. Be the first to review AC 265347 and earn rewards!
Have you used AC 265347?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image